Overview
Dry eye disease (DED), also known as dry eye syndrome (DES), keratoconjunctivitis sicca (KCS), and keratitis sicca, is a multifactorial disease of the ocular surface due to a loss of homeostasis of the tear film. It often results in ocular symptoms and visual disturbance due to underlying tear film instability, ocular suface inflammation and damage, and neuorsensory abnormalities. [1, 2] Dry eye disease is a common form of ocular surface disease (OSD) and may overlap with other causes of OSD, such as limbal steam cell insufficiency and ocular graft-versus-host disease. [3]
The ocular surface is an integrated anatomical unit consisting of seven key interactive and interdependent components: the tear film, the lacrimal and accessory lacrimal apparatus, the nasolacrimal drainage system, the eyelids, the bulbar and tarsal conjunctiva, cranial nerve V, and cranial nerve VII. [4] Abnormalities or deficiencies in any of the seven ocular surface components may worsen dry eye disease, yet promise opportunities for effective therapeutic intervention