Manufacturer: Cipla Ltd
Salt Composition : Abacavir(300mg)
Abamune L 600 mg/300 mg Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow carefully the instructions for all the medicines that you are given. It can be taken with or without food. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.
Abamune-L Tablet 30's contains Abacavir and Lamivudine. Abamune-L Tablet 30's works by interfering with the functioning of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Abamune-L Tablet 30's helps in treating HIV infection.
Abacavir is primarily metabolized via two pathways, uridine diphosphate glucuronyltransferase and alcohol dehydrogenase, resulting in the inactive glucuronide metabolite (361W94, ~36% of the dose recovered in the urine) and the inactive carboxylate metabolite (2269W93, approximately 30% of the dose recovered,The pharmacokinetics of lamivudine are similar in patients with HIV-1 or HBV infection, and healthy volunteers. The drug is rapidly absorbed after oral administration, with maximum serum concentrations usually attained 0.5 to 1.5 hours after the dose.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects are-
Fatigue
Headache
Nausea
Vomiting
Otitis media (infection of ear)
Nasal infection
Throat infection
Skin rash
Fever
Chills
Abnormal dreams
Dizziness
increased blood acidity due to high levels of lactic acid.
acute inflammation of the pancreas.
chronic inflammation of the pancreas.
a patient who is producing milk and breastfeeding.
chronic kidney disease stage 3A (moderate)
chronic kidney disease stage 3B (moderate)
Abamune L 600 mg/300 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Caution is advised when consuming alcohol with Abamune L 600 mg/300 mg Tablet. Please consult your doctor.
Abamune L 600 mg/300 mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
ABAMUNE L contains Abacavir which belongs to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs). It is indicated to treat HIV (human immunodeficiency virus) infection.
Drug-Drug Interactions: Abamune-L Tablet 30's may have interaction with the antiretroviral medications (e.g. efavirenz). Drug-Food Interactions: alcohol consumption should be avoided with Abamune-L Tablet 30's. Abamune-L Tablet 30's may interact with alcohol and alcohol-containing beverages.
Store below 30°C
If you miss a dose of Abamune L 600 mg/300 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Abacavir may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Lamivudine
You have been prescribed Lamivudine for the treatment of chronic hepatitis B virus (HBV) infection.
In combination with other medicines, it is used for the treatment of HIV infections.
Take it with food, as this increases the absorption of the medicine into the body.
Lamivudine may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may still develop infections or other illnesses associated with viral infection while taking this medication.
You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Q. Is Abacavir safe?
Abacavir is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Q. How does Abacavir work?
Abacavir works by blocking the function of an enzyme, called reverse transcriptase, which is responsible for the HIV replication process. This helps to reduce the level of HIV in the blood.
Q. What is Abacavir? What is it used for?
Abacavir belongs to a group of medicines called antiretrovirals. It is used to treat human immunodeficiency virus (HIV), which if not controlled can cause AIDS (acquired immunodeficiency syndrome). Effective control of HIV can also improve the working of the immune system.
Q. Is Abacavir effective?
Abacavir is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Abacavir too early, the symptoms may return or worsen.
Q. What is Abacavir hypersensitivity reaction?
The use of Abacavir may cause a serious or life-threatening allergic or hypersensitivity reaction. In this, one may experience fever, skin rash, nausea, vomit, diarrhea, abdominal pain, loss of appetite, severe tiredness and headache. Other symptoms of hypersensitivity may include joint or muscle pain, swelling of the neck, shortness of breath, sore throat, cough and occasionally inflammation of the eye (conjunctivitis), mouth ulcers, low blood pressure, tingling or numbness of the hands or feet. Consult your doctor immediately if you experience any of these symptoms and stop taking Abacavir immediately.
Q. What if I forget to take a dose of Abacavir?
If you forget a dose of Abacavir, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Q. How should I take Lamivudine?
Lamivudine should be taken in the dose and duration advised by the doctor. This medicine can be taken with or without food. However, it is better to take it at a fixed time of the day to avoid the chances of missing a dose.
Q. Is Lamivudine effective?
Lamivudine is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Lamivudine too early, the symptoms may return or worsen.
Q. What is drug resistance? Can I develop drug resistance with Lamivudine?
Drug resistance is a state where the medicine which was once effective in treating an infection becomes ineffective. This mainly happens due to the ability acquired by the virus or bacteria to get modified inside the body which affects the overall working of the medicine. Hence, the medicine is no longer able to fight against the virus or bacteria. Generally, drug resistance with Lamivudine is more likely to happen if you take less dose than what is recommended.
Q. How long should I take Lamivudine?
Do not stop taking entecavir without consulting your doctor. Stopping entecavir before treatment may worsen your hepatitis. This can happen during the first several months after you stop taking entecavir. Take the medicine strictly as advised and do not miss any dose.
Q. What if I forget to take a dose of Lamivudine?
If you forget a dose of Lamivudine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Q. What if HIV infection co-exists with HBV infection? Will this affect treatment with Lamivudine?
In HBV patients who are diagnosed with HIV, Lamivudine is not recommended until and unless these patients start taking medicines for HIV management. Starting Lamivudine in such patients may cause resistance to the prescribed HIV medicines. Therefore, doctors recommend tests for HIV in patients diagnosed with HBV infection before starting treatment with Lamivudine.
Q. Can Lamivudine cure hepatitis B?
No, Lamivudine does not cure hepatitis B but may improve the condition of the liver. It may decrease the amount of hepatitis B virus (HBV) present in the body. This is done by limiting the ability of HBV to multiply and further infect new liver cells.
Q. Is Lamivudine safe?
Lamivudine is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
