Manufacturer: Neon Laboratories Ltd
Salt Composition : Dactinomycin(0.5mg)
Actinocin 0.5mg Injection works by interfering with the growth of cancer cells, which are eventually destroyed. It is given under the supervision of a healthcare professional and should not be self-administered. It might be given as a single therapy or in combination with some other medication. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
Each vial contains 0.5 mg (500 mcg) of dactinomycin, USP and 20 mg of mannitol. 12.1 Mechanism of Action - Dactinomycin for injection is a cytotoxic actinomycin that binds DNA and inhibits RNA synthesis.
Dactinomycin is an antitumor antibiotic originally identified as a product of the Streptomyces yeast species. Its mechanism of action is through DNA intercalation and inhibition of RNA and protein synthesis, and it is cell cycle phase nonspecific.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Actinocin
Nausea
Vomiting
Loss of appetite
Glossitis (tongue inflammation)
Lip inflammation
Diarrhea
Inflammation of the rectum
Low blood platelets
shingles.
a bad infection.
low blood counts due to bone marrow failure.
anemia.
decreased blood platelets.
low levels of white blood cells.
low levels of a type of white blood cell called neutrophils.
a blood clot in a vein of the liver.
Actinocin 0.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Actinocin 0.5mg Injection. Please consult your doctor.
Actinocin 0.5mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Wilms Tumor.
Rhabdomyosarcoma.
Ewing Sarcoma.
Metastatic Nonseminomatous Testicular Cancer.
Gestational Trophoblastic Neoplasia.
Regional Perfusion in Locally Recurrent and Locoregional Solid Malignancies.
Recommended Dosage for Wilms Tumor.
infections.
hepatic toxicity.
live viral vaccines.
myelosuppression.
renal toxicity.
Kindly do not self administer.
Store below 30°C
Actinocin 0.5mg Injection is given as an injection into vein under the supervision of a doctor only.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and dark urine.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
