Manufacturer: Zydus Cadila
Salt Composition : Chlorzoxazone(250mg), Diclofenac(50mg), Paracetamol(325mg)
Strip of 10 Tablet Mr
(Inclusive of all taxes)
Activa MR 250 mg/50 mg/325 mg Tablet MR should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.
Activa MR 250 mg/50 mg/325 mg Tablet MR is a combination of a muscle relaxant (Chlorzoxazone) and two pain relieving medicines (Diclofenac and Paracetamol). The muscle relaxant works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm, thereby improving movement of muscles.
Analysis of plasma samples indicated a rapid absorption and rapid elimination of chlorzoxazone. Average values of the elimination half-life and plasma clearance were 1.12 +/- 0.48 hr and 148.0 +/- 39.9 ml/min, respectively.
Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs.
Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver (90-95%) and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Activa MR
Nausea
Vomiting
Heartburn
Stomach pain
Diarrhea
Loss of appetite
Dryness in mouth
meningitis not due to an infection.
systemic mastocytosis.
dehydration.
hepatic porphyria.
anemia.
increased risk of bleeding due to clotting disorder.
an increased risk of bleeding.
alcoholism.
Information regarding the use of Activa MR 250 mg/50 mg/325 mg Tablet MR during pregnancy is not available. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Activa MR 250 mg/50 mg/325 mg Tablet MR. Please consult your doctor.
Information regarding the use of Activa MR 250 mg/50 mg/325 mg Tablet MR during breastfeeding is not available. Please consult your doctor.
Activa MR Tablet is a combination of Diclofenac, Paracetamol and Chlorzoxazone medicine. It is used for the treatment of pain, swelling, and tenderness associated with muscle injury and muscle spasms. It may also be used to treat pain and swelling in post-surgical patients.
Avoid driving while consuming CHLORZOXAZONE+DICLOFENAC+PARACETAMOL as it can cause dizziness in some individuals and hamper your focus and reflexes. Avoid concomitant consumption of drugs containing the same chemicals as CHLORZOXAZONE+DICLOFENAC+PARACETAMOL as it can lead to overdosage and unwanted side effects.
Do not chew, crush or break it. Activa MR 250 mg/50 mg/325 mg Tablet MR is to be taken with food.
Store below 30°C
If you miss a dose of Activa MR 250 mg/50 mg/325 mg Tablet MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Activa MR 250 mg/50 mg/325 mg Tablet MR to relieve pain due to muscle spasm.
This medicine is most effective when taken along with proper rest and physical therapy.
Avoid consuming alcohol when taking Activa MR 250 mg/50 mg/325 mg Tablet MR as it may cause excessive drowsiness and increase the risk of liver damage.
Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Activa MR 250 mg/50 mg/325 mg Tablet MR.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Activa MR 250 mg/50 mg/325 mg Tablet MR is to be taken with food.
Q. What is Activa MR 250 mg/50 mg/325 mg Tablet MR?
Activa MR 250 mg/50 mg/325 mg Tablet MR is a combination of three medicines: Diclofenac, Paracetamol, and Chlorzoxazone. This medication helps in relieving muscle pain. Chlorzoxazone is a muscle relaxant which works by acting on the central nervous system. Diclofenac and Paracetamol work by lowering the chemical substance (prostaglandins) in the body that causes pain and inflammation.
Q. Is it safe to use Activa MR 250 mg/50 mg/325 mg Tablet MR?
Activa MR 250 mg/50 mg/325 mg Tablet MR is safe for most of the patients. However, in some patients it may cause common side effects like nausea, vomiting, heartburn, stomach pain, diarrhea, loss of appetite, dryness in the mouth, weakness, sleepiness and other uncommon or rare side effects. Inform your doctor as soon as possible if you experience any persistent problem due to the medication.
Q. Can I stop taking Activa MR 250 mg/50 mg/325 mg Tablet MR when my pain is relieved?
Activa MR 250 mg/50 mg/325 mg Tablet MR should be continued if advised for a specific time duration by your doctor. However, it can be discontinued if you are using it for short-term pain relief.
Q. Can the use of Activa MR 250 mg/50 mg/325 mg Tablet MR cause nausea and vomiting?
Yes, the use of Activa MR 250 mg/50 mg/325 mg Tablet MR can cause nausea and vomiting. In case, you experience nausea while taking this medicine, take it with milk, food or with antacids. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to your doctor.
Q. Can the use of Activa MR 250 mg/50 mg/325 mg Tablet MR cause dizziness?
Yes, the use of Activa MR 250 mg/50 mg/325 mg Tablet MR can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for sometime and resume once you feel better.
Q. Can the use of Activa MR 250 mg/50 mg/325 mg Tablet MR cause damage to kidneys?
Yes, the long-term use of Activa MR 250 mg/50 mg/325 mg Tablet MR can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
Q. Can I take a higher than the recommended dose of this medicine?
No, taking a higher than the recommended dose of Activa MR 250 mg/50 mg/325 mg Tablet MR can increase the risks of side effects. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Q. What are the recommended storage conditions for Activa MR 250 mg/50 mg/325 mg Tablet MR?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
