Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Perindopril erbumine, Losartan
Strip of 10 Tablet
(Inclusive of all taxes)
If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor’s advice while taking this medicine. Nausea, indigestion, stomach pain, and taste change are some common side effects. It may also cause dizziness initially, but this improves with time. This medicine may cause increase in potassium levels (hyperkalemia). Hence, avoid taking potassium rich food or supplements. Regular monitoring of blood pressure is required while taking this medicine. Before taking this medicine, tell your doctor if you are pregnant if you have ever had any problems with your blood circulation or have liver or kidney problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
perindopril erbumine Tablets is a pro-drug for perindoprilat, which inhibits ACE in human subjects and animals. The mechanism through which perindoprilat lowers blood pressure is believed to be primarily inhibition of ACE activity.
Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland).
Pharmacokinetics: Oral administration of ACEON® (perindopril erbumine) Tablets results in its rapid absorption with peak plasma concentrations occurring at approximately 1 hour. The absolute oral bioavailability of perindopril is about 75%.
The major metabolic pathway for losartan is by the cytochrome P450 (CYP) 3A4, 2C9 and 2C10 isoenzymes. Overall, losartan has a favorable drug-drug interaction profile, as evidenced by the lack of clinically relevant interactions between this drug and a range of inhibitors and stimulators of the CYP450 system.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Adpep R
Nausea
Taste change
Stomach pain
Indigestion
Diarrhea
Cough
Headache
Dizziness
Weakness
Decreased blood pressure
Increased potassium level in blood
high levels of potassium in the blood.
inherited disorder of continuing episodes of swelling.
decreased function of bone marrow.
low levels of a type of white blood cell called neutrophils.
renal artery stenosis.
low blood pressure.
liver problems.
decreased kidney function.
Adpep R Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Adpep R Tablet.
Adpep R Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Perindopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to prevent heart attacks in people with a certain type of heart disease (stable coronary artery disease).
Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Some products that may interact with this drug include: aliskiren, gold injections, lithium, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan.
Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).
Do not chew, crush or break it. Adpep R Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Adpep R Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Adpep R Tablet for the treatment of high blood pressure.
Lowering high blood pressure helps prevent strokes and heart attacks.
It may cause dizziness. Get up slowly when rising from a sitting or lying position.
It may cause the level of potassium in blood to go up. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
It can be harmful to an unborn baby. Do not take it during pregnancy or breastfeeding. Tell your doctor if you become pregnant while taking Adpep R Tablet.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adpep R Tablet is to be taken empty stomach.
