Manufacturer: Pfizer Ltd
Salt Composition : Doxorubicin(Plain)(2mg/ml)
It is given as a drip or infusion vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to both male and female to use reliable contraception during the treatment.
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation.
Up to several weeks after administration, significant concentrations of doxorubicin have been found in haematopoietic cells and in several other tissues. The maximum cellular doxorubicin concentrations reached in vivo remain significantly below those at which all clonogenic leukaemic cells are killed in vitro.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Adriblastina
Vomiting
Allergic reaction
Nausea
Mouth sore
Hair loss
Stomach pain
Eye disorder
Increased thirst
Arrhythmia (irregular heartbeats)
Nail disorder
a bad infection.
glucose-6-phosphate dehydrogenase (G6PD) deficiency.
anemia.
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
heart attack within the last 30 days.
cardiomyopathy, a disease of the heart muscle.
Adriblastina Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Adriblastina Injection. Please consult your doctor.
Adriblastina Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Adriblastina Injection is used in the treatment of various types of cancers of blood, breast, lung, ovaries and soft tissues. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.
Some products that may interact with this drug include: digoxin, progesterone, streptozocin, stavudine, trastuzumab, zidovudine. Other medications can affect the removal of doxorubicin from your body, which may affect how doxorubicin works.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
Adriblastina Injection is given as an injection into the vein under the supervision of a doctor.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, blood cell count in your blood.
Inform your doctor if you experience fever, chills, shortness of breath and swelling of face or lips.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How does doxorubicin work?
Doxorubicin is anti-cancer or antineoplastic chemotherapy drug that belongs to a class of medications called anthracyclines. It slows down or stops the growth of cancer cells by interfering with DNA of the cancer cells. This helps treat the cancer.
Q. Is doxorubicin a vesicant?
Yes doxorubicin is a vesicant (irritant).
