Manufacturer: Strides shasun Ltd
Salt Composition : Glimepiride(2mg), Metformin(500mg), Rosiglitazone(2mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Adride RM 2 mg/500 mg/2 mg Tablet should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia).
Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors. Not all secondary sulfonylureas have the same risk of hypoglycemia.
Glimepiride is completely metabolized by oxidative biotransformation after either an IV or oral dose. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2). Cytochrome P450 2C9 has been shown to be involved in the biotransformation of glimepiride to M1.
Pharmacokinetics. Metformin has an oral bioavailability of 50–60% under fasting conditions, and is absorbed slowly. Peak plasma concentrations (Cmax) are reached within 1–3 hours of taking immediate-release metformin and 4–8 hours with extended-release formulations.
Rosiglitazone is approximately 99.8% bound to plasma proteins, primarily albumin. Metabolism: Rosiglitazone is extensively metabolized with no unchanged drug excreted in the urine. The major routes of metabolism were N-demethylation and hydroxylation, followed by conjugation with sulfate and glucuronic acid.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Adride RM
Hypoglycemia (low blood glucose level)
Nausea
Taste change
Diarrhea
Stomach pain
Headache
Edema (swelling)
Weight gain
Blurred vision
Bone fracture
Respiratory tract infection
low blood sugar.
pituitary hormone deficiency.
a condition where the adrenal glands produce less hormones called Addison's disease.
glucose-6-phosphate dehydrogenase (G6PD) deficiency.
hepatic porphyria.
a type of blood disorder where the red blood cells burst called hemolytic anemia.
Adride RM 2 mg/500 mg/2 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Adride RM 2 mg/500 mg/2 mg Tablet.
Information regarding the use of Adride RM 2 mg/500 mg/2 mg Tablet during breastfeeding is not available. Please consult your doctor.
Rosiglitazone and metformin combination is used to treat a type of diabetes mellitus called type 2 diabetes. It is used together with a proper diet and exercise to help control blood sugar levels.
atypical antipsychotics (e.g. olanzapine and clozapine)
thiazides and other diuretics.
corticosteroids.
estrogens.
Do not chew, crush or break it. Adride RM 2 mg/500 mg/2 mg Tablet is to be taken with food.
Store below 30°C
Take it with food to lower your chance of having an upset stomach.
It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adride RM 2 mg/500 mg/2 mg Tablet is to be taken with food.
