Manufacturer: Alembic Pharmaceuticals Ltd
Salt Composition : Hydroquinone(2% w/w), Tretinoin(0.025% w/w), Fluocinolone acetonide(0.01% w/w)
Tube of 15gm Cream
(Inclusive of all taxes)
Advan-THF Cream should be used in the dose and duration as advised by your doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. It is for external use only. Do not use this medicine more than the recommended dose. Inform your doctor if you have known allergies from this medicine. The common side effects of this medicine include burning, irritation, itching and redness at the application site.
Advan-THF Cream helps to lighten these dark patches by reducing the production of melanin (natural skin pigment). It lightens skin color and gives a smoother-looking skin. Advan-THF Cream also reduces any swelling, redness and itchiness especially if you have a sensitive skin.
Hydroquinone is absorbed through the skin and metabolized primarily to sulfate and glucuronide conjugates, which are excreted in the urine. Additional metabolites include benzoquinone, multiple glutathione conjugates, and N-acetyl cysteine conjugates.
The principal mechanisms proposed to explain the increased disappearance of tretinoin from plasma include: (i) decreased intestinal absorption; (ii) enhanced enzymatic catabolism; and (iii) the induction of cytoplasmic retinoic acid binding proteins (CRABP), which leads to increased drug sequestration.
The reported half-life of fluocinolone acetonide ranges between 1.3-1.7 hours. This pharmacokinetic parameter is not relevant as the systemic absorption of fluocinolone acetonide is very minimal and the concentration in urine is lower than the minimum quantitation limit.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Advan-THF
Application site reactions (burning, irritation, itching and redness)
burning, itching, irritation, redness, or drying of the skin.
acne.
change in skin color.
bruising or shiny skin.
tiny red bumps or rash around the mouth.
small white or red bumps on the skin.
Advan-THF Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Advan-THF Cream is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
FLUOCINOLONE; HYDROQUINONE; TRETINOIN (floo oh SIN oh lone; hye droe KWIN ohn; TRET i noe in) is a combination of a corticosteroid, a retinoid similar to vitamin A, and a drug used to lighten the skin. It is used on the skin to treat melasma.
darkening or discoloration of treated skin;
irritation of your eyes, nose, or mouth;
severe skin redness, itching, peeling, blistering, or crusting;
severe burning or swelling of the skin.
Check the label for directions before use. Clean and dry the affected area and apply the cream.
Store below 30°C
If you miss a dose of Advan-THF Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Advan-THF Cream to reduce skin pigmentation.
Along with applying Advan-THF Cream, wear long-sleeved clothing, sunglasses, hat whenever you step outside in the hot sun for better protection.
Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor.
Use moisturizer regularly to overcome skin dryness during the course of treatment.
You may also use certain safe cosmetics (after consulting with your doctor) in order to lighten pigmentation.
Before using Advan-THF Cream, inform your doctor if you have any skin problems or are applying any other medicines to your skin.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
