Manufacturer: Cadila Pharmaceuticals Ltd
Salt Composition : Glibenclamide(2.5mg)
Afdiex 2.5mg Tablet may be used by itself or along with other medicines. It should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working. You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease, or some hormonal conditions. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
The mechanism of action of the drug consists in the inhibition of the ATP-sensitive K+ channels, which leads to depolarization of the cells and insulin secretion. Based on the same mechanism are also the extrapancreatic action of the drug at the liver, skeletal muscle, heart muscle and smooth muscle sites.
Background: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Afdiex
Hypoglycemia (low blood glucose level)
Nausea
Headache
Dizziness
low blood sugar.
pituitary hormone deficiency.
a condition where the adrenal glands produce less hormones called Addison's disease.
hepatic porphyria.
a type of blood disorder where the red blood cells burst called hemolytic anemia.
alcoholism.
liver problems.
severe liver disease.
Afdiex 2.5mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Afdiex 2.5mg Tablet.
Afdiex 2.5mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Afdiex 2.5mg Tablet
Glibenclamide is used to lower the blood sugar level in patients with type 2 diabetes mellitus that is not controlled by diet and exercise alone. . It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Glibenclamide is an antidiabetic medication.
cardiovascular risk.
renal/liver disease.
hypoglycemia.
G6PD deficiency.
hyponatremia.
Do not chew, crush or break it. Afdiex 2.5mg Tablet is to be taken with food.
Store below 30°C
You should skip a dose of Afdiex 2.5mg Tablet if a meal is skipped, and add a dose of medicine if you eat an extra meal.
Consult a doctor before taking any medicines.
Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
Be careful while driving or operating machinery until you know how Afdiex 2.5mg Tablet affects you.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Afdiex 2.5mg Tablet is to be taken with food.
Q. Is Afdiex 2.5mg Tablet the same as Glipizide?
No, Afdiex 2.5mg Tablet and Glipizide are different medicines. However, they belong to the same class of medicines called sulfonylureas and are used to treat type 2 diabetes mellitus in adults.
Q. Does Afdiex 2.5mg Tablet play any role in the treatment of polycystic ovarian syndrome (PCOS)?
No, Afdiex 2.5mg Tablet is not known to have any role in the treatment of polycystic ovarian syndrome (PCOS). Also, there is no clinical evidence available regarding the same.
Q. Why should Afdiex 2.5mg Tablet be used cautiously in elderly patients?
Afdiex 2.5mg Tablet should be used with extra caution in elderly patients because they are at high risk of getting low blood sugar (hypoglycemic event).
Q. Is Afdiex 2.5mg Tablet useful in the management of prediabetes?
Afdiex 2.5mg Tablet is not used for the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. There are clinical studies available, but the evidence is not strong enough for its use in prediabetes.
Q. How is Afdiex 2.5mg Tablet different from Teneligliptin?
Both Afdiex 2.5mg Tablet and Teneligliptin are antidiabetic medicines and control blood sugar levels effectively. However, they work in different ways and may show different kinds of side effects. Afdiex 2.5mg Tablet commonly causes hypoglycemia and weight gain while Teneligliptin causes headache and nasopharyngitis. Teneligliptin causes hypoglycemia when used along with insulins or sulfonylureas and does not cause weight gain.
Q. Can I skip Afdiex 2.5mg Tablet for a few days?
No, Afdiex 2.5mg Tablet should not be skipped as it can make your diabetes worse. If you miss the dose by mistake, take it as soon as you remember.
Q. Can I take Afdiex 2.5mg Tablet if I have a sulfa allergy?
Use of Afdiex 2.5mg Tablet should be avoided if you are allergic (hypersensitive) to sulfonylureas or sulfonamides or any of the other ingredients of this medicine.
Q. Does Afdiex 2.5mg Tablet cause weight gain?
Yes, Afdiex 2.5mg Tablet can cause weight gain. It is advisable to closely monitor your diet and exercise regularly while taking this medicine. Avoid skipping your meals as it can cause very low blood sugar levels and you may end up snacking or taking a lot of sugars.
Q. Is there any benefit of taking Afdiex 2.5mg Tablet with insulin?
Afdiex 2.5mg Tablet, when used with insulin, can help to control high blood sugar levels. Taking them together can help to lower the dose of insulin but there could also be an increased risk of hypoglycemia (low blood sugar levels). The dose of these medicines may need to be adjusted along with regular blood sugar level monitoring. Please consult your doctor if you have any doubts and follow your doctor's instructions carefully to get maximum benefit of Afdiex 2.5mg Tablet.
Q. Is it safe to take Afdiex 2.5mg Tablet with Liraglutide?
Yes, Afdiex 2.5mg Tablet and Liraglutide can be taken together, as they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as a dose adjustment of the two may be needed.
Q. Is Afdiex 2.5mg Tablet a Thiazolidinedione?
No, Afdiex 2.5mg Tablet is not a Thiazolidinedione, it is a sulfonylurea. However, both are antidiabetic medicines but belong to a different group of medicines.
Q. Is Afdiex 2.5mg Tablet useful in the management of gestational diabetes?
The use of insulin is advised during pregnancy to control the blood glucose levels. Insulin injections are the standard medication for gestational diabetes. Afdiex 2.5mg Tablet may be advised as an alternative or in addition to insulin for the management of gestational diabetes. However, do not start taking Afdiex 2.5mg Tablet until prescribed by the doctor.
Q. Does Afdiex 2.5mg Tablet cause hair loss?
No, hair loss is not seen with the use of Afdiex 2.5mg Tablet. However, diabetes can lead to hair loss. Talk to your doctor if you have excessive hair loss as it could be due to some other underlying condition or it could be a sign of your diabetes getting worsened.
Q. Is it safe to take Afdiex 2.5mg Tablet with pioglitazone?
Yes, it is safe to take Afdiex 2.5mg Tablet with Pioglitazone in patients with diabetes mellitus. Together these two medicines can control your blood sugar levels, lower plasma lipid levels and improve blood pressure. However, the risk of very low blood sugar levels can increase and the dose of these medicines may need to be adjusted.
