Manufacturer: Alkem Laboratories Ltd
Salt Composition : Piroxicam(20mg)
Alkem Piroxicam Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine. Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
Alkem Piroxicam Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).
The pharmacokinetics of piroxicam are linear. Proportional increase in exposure is observed with increasing doses. The prolonged half-life (50 hours) results in the maintenance of relatively stable plasma concentrations throughout the day on once daily doses and significant accumulation upon multiple dosing.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Alkem Piroxicam
Injection site reactions (pain, swelling, redness)
Vomiting
Stomach pain
Nausea
Headache
Dizziness
systemic mastocytosis.
anemia.
increased risk of bleeding due to clotting disorder.
an increased risk of bleeding.
alcoholism.
high blood pressure.
a heart attack.
chronic heart failure.
Alkem Piroxicam Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Caution is advised when consuming alcohol with Alkem Piroxicam Injection. Please consult your doctor.
Alkem Piroxicam Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Alkem Piroxicam Injection is a pain-relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable.
Nonsteroidal anti-inflammatory drugs. Taking piroxicam with other NSAIDs may increase side effects, including stomach pain.
Disease-modifying anti-inflammatory drug.
Blood pressure drugs.
Anticoagulant/blood thinner.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Alkem Piroxicam Injection, consult your doctor.
Consult a doctor before taking any medicines.
Alkem Piroxicam Injection helps relieve pain and swelling of various joints and muscles.
It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What is the difference between Alkem Piroxicam Injection and diclofenac?
Both Alkem Piroxicam Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Alkem Piroxicam Injection.
Q. What is the difference between Alkem Piroxicam Injection and naproxen?
Both Alkem Piroxicam Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Alkem Piroxicam Injection.
Q. What is the difference between Alkem Piroxicam Injection and meloxicam?
Both Alkem Piroxicam Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Alkem Piroxicam Injection.
Q. What is the difference between Alkem Piroxicam Injection and ketoprofen?
Both Alkem Piroxicam Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Alkem Piroxicam Injection. Ketoprofen gel also showed excellent tolerability.
Q. What is the difference between Alkem Piroxicam Injection and tramadol?
Alkem Piroxicam Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Q. What is the difference between Alkem Piroxicam Injection and nimesulide?
Both Alkem Piroxicam Injection and nimesulide are pain killers. However, Alkem Piroxicam Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Q. Can Alkem Piroxicam Injection be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Alkem Piroxicam Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Alkem Piroxicam Injection.
Q. Are Alkem Piroxicam Injection and aspirin same?
No. Alkem Piroxicam Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
Q. Can Alkem Piroxicam Injection be used along with dexamethasone?
No. Alkem Piroxicam Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Q. Can Alkem Piroxicam Injection be used with methocarbamol?
Yes. Methocarbamol can be used with Alkem Piroxicam Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Q. Can Alkem Piroxicam Injection be used along with paracetamol?
Yes. Paracetamol can be used with Alkem Piroxicam Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Q. Is Alkem Piroxicam Injection a NSAID?
Yes. Alkem Piroxicam Injection is a non-steroidal anti-inflammatory drug (NSAID).
Q. Is Alkem Piroxicam Injection a sulfa drug?
Alkem Piroxicam Injection is a sulphur containing compound. Alkem Piroxicam Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
Q. Is Alkem Piroxicam Injection a blood thinner?
No. Alkem Piroxicam Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
Q. Is Alkem Piroxicam Injection a muscle relaxant?
No. Alkem Piroxicam Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
Q. Is Alkem Piroxicam Injection a narcotic?
No. Alkem Piroxicam Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
Q. Can Alkem Piroxicam Injection be used in hypertension?
No. Alkem Piroxicam Injection is not a medication to control hypertension. It is important to note that Alkem Piroxicam Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Alkem Piroxicam Injection.
Q. Can Alkem Piroxicam Injection be used along with Losartan?
No. Alkem Piroxicam Injection should not be combined with Losartan. It is important to note that Alkem Piroxicam Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Alkem Piroxicam Injection.
Q. Can Alkem Piroxicam Injection be used with Lisinopril?
No. Alkem Piroxicam Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Alkem Piroxicam Injection.
Q. Can Alkem Piroxicam Injection be used with calcium channel blocker?
Yes. Alkem Piroxicam Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Q. Can Alkem Piroxicam Injection be used with Tizanidine?
Yes, Alkem Piroxicam Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Q. Why is beta cyclodextrin added to Alkem Piroxicam Injection?
Yes. Alkem Piroxicam Injection can be combined with beta-cyclodextrin. Research has shown that combining Alkem Piroxicam Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Q. Are there any alternatives of Alkem Piroxicam Injection?
Yes. There are alternatives to Alkem Piroxicam Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Q. What are the contraindications for Alkem Piroxicam Injection?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
Q. Can Alkem Piroxicam Injection be used in the treatment of allergy?
No. Alkem Piroxicam Injection is not a drug to treat allergy. It is a pain killer.
Q. How long does Alkem Piroxicam Injection work?
Alkem Piroxicam Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
Q. Can you get high by using Alkem Piroxicam Injection?
No. Alkem Piroxicam Injection is not known to cause high. It is a non-narcotic painkiller.
Q. Can Alkem Piroxicam Injection be used to treat menstrual cramp?
Alkem Piroxicam Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Q. Can I use Alkem Piroxicam Injection for a migraine?
Alkem Piroxicam Injection is not approved for the treatment of migraine. Research studies have shown that Alkem Piroxicam Injection is effective in significantly decreasing the pain associated with migraine without aura.
Q. Is Alkem Piroxicam Injection effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Alkem Piroxicam Injection as the cause of back pain can be different for different person.
Q. Is Alkem Piroxicam Injection affective in gout management?
Yes. Alkem Piroxicam Injection can be given for the treatment of acute gout. Research studies have shown Alkem Piroxicam Injection to be highly effective in the treatment of acute gout.
Q. Can you donate blood when on the medication with Alkem Piroxicam Injection?
Yes. You can donate blood when on Alkem Piroxicam Injection. Do inform your doctor before donating blood.
Q. Can I use Alkem Piroxicam Injection if I am a diabetic?
Alkem Piroxicam Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Alkem Piroxicam Injection so taking piroxicam can lead to increased risk of renal failure by many folds.
Q. Can I use Alkem Piroxicam Injection if I have a deranged renal function?
No. Alkem Piroxicam Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Q. Can Alkem Piroxicam Injection lead to skin reactions?
Yes. Alkem Piroxicam Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
Q. Can I use Alkem Piroxicam Injection if I am pregnant?
No. Alkem Piroxicam Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
Q. Can I use Alkem Piroxicam Injection if I have peptic ulcer disease?
No. Alkem Piroxicam Injection is contraindicated in cases of active peptic ulcer disease. Alkem Piroxicam Injection is known to cause gastric ulceration and bleeding.
Q. Can I use Alkem Piroxicam Injection if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Q. Can Alkem Piroxicam Injection lead to difficulty in conception?
Yes. Alkem Piroxicam Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Q. Can Alkem Piroxicam Injection be used with diuretics?
No. Alkem Piroxicam Injection should not be used with diuretics. Alkem Piroxicam Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Q. Can Alkem Piroxicam Injection be used with lithium?
No. Alkem Piroxicam Injection should not be used with lithium. Alkem Piroxicam Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
Q. Can Alkem Piroxicam Injection be used with warfarin?
No. Alkem Piroxicam Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
Q. What increases the chances of getting a gastric ulcer when I am already taking Alkem Piroxicam Injection?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Alkem Piroxicam Injection?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
Q. What are the serious side effects of Alkem Piroxicam Injection?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.
