Manufacturer: Mylan Pharmaceuticals Pvt Ltd
Salt Composition : Amphotericin B(50mg)
Ambisome Injection is generally administered by a doctor or a nurse. You should not self-administer this medicine at home. The dose and duration of the treatment will depend on the severity of your condition. You should get the injection as long as your doctor has prescribed it. To make sure it is safe for you, before using this medicine, let your doctor know if you have any preexisting medical conditions or if you are taking any other medicines. Let your doctor also know if you are pregnant or breastfeeding, as it may cause harmful effects to the developing baby.
Mechanism of Action. Amphotericin B binds to ergosterol in the fungal cell membrane, which leads to the formation of pores, ion leakage and ultimately fungal cell death.
Liposomal amphotericin B produced higher plasma concentrations and lower apparent distribution volumes and greatly reduced renal and fecal clearances, suggesting that it constitutes a stable intravenous drug delivery system that remains in the circulation for a period of time and significantly alters.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ambisome
Decreased potassium level in blood
Nausea
Vomiting
Chills
Fever
systemic mastocytosis.
low amount of magnesium in the blood.
low amount of potassium in the blood.
decreased kidney function.
Ambisome Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is not known whether it is safe to consume alcohol with Ambisome Injection. Please consult your doctor.
Ambisome Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Amphotericin B liposomal injection is used to treat fungal infections such as cryptococcal meningitis (a fungal infection of the lining of the spinal cord and brain) and visceral leishmaniasis (a parasitic disease that usually affects spleen, liver, and bone marrow) in certain people.
Some products that may interact with this drug include: anti-cancer drugs (such as mechlorethamine, nitrogen mustard), azole antifungals (such as ketoconazole, itraconazole), cidofovir, digoxin, flucytosine, medications that affect the kidneys (including pentamidine, tacrolimus, aminoglycosides such as gentamicin).
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How is Ambisome Injection administered?
Ambisome Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Ambisome Injection.
Q. Is Ambisome Injection fungistatic or fungicidal?
Ambisome Injection is fungicidal in nature, which means it acts by killing the fungus.
Q. What should I tell my doctor before starting treatment with Ambisome Injection?
Before starting treatment with Ambisome Injection, tell your doctor if you have any other health problems, like kidney or liver-related issues. This is because certain medical conditions may affect your treatment and you may even need dose modifications. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are planning a baby, if you are pregnant or breastfeeding.
Q. Is Ambisome Injection an antibiotic?
Yes, Ambisome Injection is an antifungal antibiotic for the treatment of infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells and Visceral leishmaniasis (an infectious disease caused by a parasite).
Q. Is Ambisome Injection testing dose needed?
Yes, administration of Ambisome Injection is associated with allergic reaction (severe and serious allergic), therefore it is recommended to administer a testing dose before starting the treatment to check for any sensitivity to the medicine.
