Manufacturer: Vhb Life Sciences Inc
Salt Composition : Amifostine(500mg)
Amfos 500mg Injection is given as an injection into vein (IV infusion) under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Before taking it, tell your doctor if you have heart diseases such as irregular heartbeat and heart failure, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.
Amfos 500mg Injection works by removing free radical, harmful elements produced by cisplatin (a medicine used to treat cancer) or radiation therapy in tissues.
Amifostine (Ethyol) administered to cancer patients is rapidly cleared from plasma by a biphasic decay with an alpha half-life (T1/2 alpha) of 0.88 min and a T1/2 beta of 8.8 min. The result is that more than 90% of the drug has disappeared from the plasma compartment 6 min after intravenous (i.v.) administration.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amfos
Nausea
Vomiting
Decreased blood pressure
Hiccup
Sleepiness
Dizziness
Flushing (sense of warmth in the face, ears, neck and trunk)
Fever
Chills
low amount of calcium in the blood.
dehydration.
a low supply of oxygen rich blood to the heart.
abnormal heart rhythm.
chronic heart failure.
a transient ischemic attack, a type of stroke that lasts only a few minutes.
a stroke.
low blood pressure.
Amfos 500mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Amfos 500mg Injection. Please consult your doctor.
Amfos 500mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the hypotensive activities of Amifostine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Amifostine is combined with Arsenic trioxide.
Kindly do not self administer.
Store below 30°C
Amfos 500mg Injection is given as an infusion into the vein ( IV infusion) under the supervision of a doctor only.
It is advisable to stay hydrated or drink plenty of fluids before taking medicine.
You will be monitored for blood pressure before and after every 5 minutes of infusion.
It may cause a decrease in calcium levels. Your doctor may monitor your calcium levels regularly and prescribe supplements if needed.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Amfos 500mg Injection FDA approved?
Yes, it is FDA an approved drug
Q. What is Amfos 500mg Injection used for?
Amfos 500mg Injection is used to reduce toxicity to kidneys associated with cisplatin therapy in patients with advanced ovarian cancer, and in prevention of dry mouth (xerostomia) during radiotherapy for head and neck cancer
Q. How does Amfos 500mg Injection work?
It protects the normal cells against the harmful effects of chemotherapy medications and radiation treatment by producing a chemical ‘thiol' that binds to and detoxifies the harmful compounds produced by cisplatin. Amfos 500mg Injection does not interfere with the action of cisplatin.
