Manufacturer: Torrent Pharmaceuticals Ltd
Salt Composition : Furosemide(20mg), Spironolactone(50mg)
Strip of 10 Tablet
(Inclusive of all taxes)
It is best to take Amifru-S Tablet in the morning along with food in order to avoid frequent urination at night time. For better results, it is suggested to take it at the same time every day. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. It is generally safe to use during breastfeeding. Before taking this medicine, tell your doctor if you have any liver or kidney disease or pregnant. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Amifru-S Tablet helps get rid of the extra water and electrolytes from your body by increasing the amount of urine produced. This enables your body to get rid of extra water thereby relieving symptoms such as shortness of breath and swelling in your arms, legs, or abdomen.
The drug is 97.6 % bound to plasma albumins. The unbound fraction of the drug rapidly increases with albumin concentration below 2 gm per 100 ml. The half-life of furosemide ranges from 0.33 to 1.17 hours in healthy subjects, and from 4.9 to 9.7 hours in patients with advanced renal failure.
The mean time to reach peak plasma concentration of spironolactone and the active metabolite, canrenone, in healthy volunteers is 2.6 and 4.3 hours, respectively. Effect of food: Food increased the bioavailability of spironolactone (as measured by AUC) by approximately 95.4%.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amifru-S
Breast enlargement in male
Electrolyte imbalance
Volume depletion
Contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia, hyponatremia, severe renal impairment, acute renal failure, anuria, Addison's disease, hypersensitivity to spironolactone.
diabetes.
a type of joint disorder due to excess uric acid in the blood called gout.
low amount of magnesium in the blood.
low amount of calcium in the blood.
low amount of sodium in the blood.
low amount of potassium in the blood.
low amount of chloride in the blood.
hearing loss.
Amifru-S Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Amifru-S Tablet.
Amifru-S Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
FUROSEMIDE+SPIRONOLACTONE belongs to a class of medicine called 'diuretics' (water pills) which helps to remove excess water from the body. Besides this, it also maintains the level of potassium in the bloodstream and prevents hypertension (high blood pressure due to oedema (fluid retention).
Drug-Drug Interaction: FUROSEMIDE+SPIRONOLACTONE may interact with other high blood pressure-lowering pills (metoprolol, ramipril, hydrochlorothiazide, atorvastatin), and it can lower your blood pressure leading to severe condition.
Do not chew, crush or break it. Amifru-S Tablet
Store below 30°C
If you miss a dose of Amifru-S Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Amifru-S Tablet helps removes excess water from your body.
Take it in the morning with breakfast to avoid getting up at night to urinate.
It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
It may cause excessive urine production, dehydration, and low electrolyte levels. Notify your doctor if you experience dizziness, tiredness, or muscle weakness that doesn't go away.
Your doctor may regularly monitor your blood pressure, kidney function and the level of salts such as potassium and sodium in your blood while you're taking this medication.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amifru-S Tablet is to be taken with food.
Avoid Amifru-S Tablet with dietary sodium.
Q. What are the recommended storage conditions for Amifru-S Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. What are the contraindications associated with the use of Amifru-S Tablet?
The use of Amifru-S Tablet should be avoided in patients with hypersensitivity to furosemide, sulfonylureas or spironolactone or any other ingredient of the product. The use of this medicine should also be avoided in patients with anuria, acute renal insufficiency, hepatic coma and pre-coma, low blood pressure (hypotension), cardiac arrhythmias, patients taking aminoglycosides or cephalosporins, kidney dysfunction due to drugs which cause renal damage, patients with high potassium levels (hyperkalemia), Addison's disease and in children with moderate to severe renal impairment.
Q. What is Amifru-S Tablet?
Amifru-S Tablet is a fixed-dose combination of furosemide (a loop diuretic) and spironolactone (an antagonist of aldosterone). Both are diuretics and they help to remove excess fluid from the body. The use of this combination is advised in patients of congestive heart failure (heart failure leading to fluid accumulation in the lung and rest of the body), nephrotic syndrome (a kidney disorder), liver cirrhosis with fluid retention (edema) and swelling of the abdomen (ascites).
Q. Is it safe to use Amifru-S Tablet?
Yes, Amifru-S Tablet is safe for most of the patients. However, in some patients it may cause common side effects like dizziness, dehydration, decreased sodium level in blood, breast enlargement in males, decreased magnesium level in blood, decreased calcium level in blood, increased blood uric acid. Inform your doctor if you experience any persistent problem while taking this medicine.
Q. Can the use of Amifru-S Tablet cause dizziness?
Yes, the use of Amifru-S Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better. Do not drive or use any machines.
Q. Can the use of Amifru-S Tablet cause gout?
Yes, Amifru-S Tablet can cause gout. Amifru-S Tablet contains furosemide which can increase the blood uric acid levels by increasing its absorption from the kidneys. Increased uric acid levels can cause a gout attack. Inform your doctor if you have hyperuricemia (excess of uric acid in blood) or a history of gout before taking this medicine. Use of Amifru-S Tablet should be avoided in patients with gout.
