Manufacturer: Medispan Ltd
Salt Composition : Rifampicin(100mg), Isoniazid(50mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Antibin Kid 100 mg/50 mg Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.
Antibin Kid 100 mg/50 mg Tablet is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.
Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Mechanism of action — The antimicrobial activity of INH is selective for mycobacteria, likely due to its ability to inhibit mycolic acid synthesis, which interferes with cell wall synthesis, thereby producing a bactericidal effect
Mechanism of action — Rifampin is thought to inhibit bacterial DNA-dependent RNA polymerase, which appears to occur as a result of drug binding in the polymerase subunit deep within the DNA/RNA channel, facilitating direct blocking of the elongating RNA. This effect is thought to be concentration related
Isonicotinyl hydrazine or isoniazid (INH) has been the mainstay of TB treatment and prevention in both adults and children. When given orally in the fasted state, INH is rapidly absorbed with the maximum concentration (Cmax) occurring 1–2 hours post-dose. Food delays and decreases the extent of absorption.
Approximately 80% of rifampicin is transported in blood bound to plasma proteins, mainly albumin. Rifampicin is well distributed, although to a different degree, in the various tissues of the human body. Probably in the hepatocyte, rifampicin undergoes a process of desacetylation.
Dark colored urine
Rash
Vomiting
Jaundice
Fever
Increased liver enzymes
Nausea
Peripheral neuropathy (tingling and numbness of feet and hand)
Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug- induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology.
diabetes.
a type of joint disorder due to excess uric acid in the blood called gout.
porphyria.
alcoholism.
decreased blood-clotting from low vitamin K.
thrombotic thrombocytopenic purpura, a type of blood disorder.
liver problems.
abnormal liver function tests.
Antibin Kid 100 mg/50 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Antibin Kid 100 mg/50 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Antibin Kid 100 mg/50 mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Tuberculosis: Rifampicin, used in combination with other active anti-tuberculosis drugs, is indicated in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifampicin is also effective against most atypical strains of mycobacteria
Studies and case reports have demonstrated that rifampin accelerates the metabolism of several drugs, including oral anticoagulants, oral contraceptives, glucocorticoids, digitoxin, quinidine, methadone, hypoglycemics, and barbiturates
Do not chew, crush or break it. Antibin Kid 100 mg/50 mg Tablet is to be taken empty stomach.
Avoid Antibin Kid 100 mg/50 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Store below 30°C
If you miss a dose of Antibin Kid 100 mg/50 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
You have been prescribed Antibin Kid 100 mg/50 mg Tablet for the treatment of tuberculosis.
Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
Take it on an empty stomach, preferably at the same time everyday.
It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Avoid drinking alcohol while taking Antibin Kid 100 mg/50 mg Tablet as this may increase the risk of side effects on the liver.
Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Antibin Kid 100 mg/50 mg Tablet as it may make hormonal contraceptives such as the pill less effective.
Do not take indigestion remedies (antacids) within at least two hours of taking Antibin Kid 100 mg/50 mg Tablet.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Antibin Kid 100 mg/50 mg Tablet is to be taken empty stomach.
Avoid Antibin Kid 100 mg/50 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Q. What is Antibin Kid 100 mg/50 mg Tablet?
Antibin Kid 100 mg/50 mg Tablet is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Q. What is the most important information I should know about the Antibin Kid 100 mg/50 mg Tablet?
Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
Q. What is the best time to take Antibin Kid 100 mg/50 mg Tablet?
Take Antibin Kid 100 mg/50 mg Tablet exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Q. Does Antibin Kid 100 mg/50 mg Tablet cause change in urine color/turn urine orange?
Yes, Antibin Kid 100 mg/50 mg Tablet can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.
