Manufacturer: Torrent Pharmaceuticals Ltd
Salt Composition : Isoniazid(450mg), Pyrazinamide(300mg), Rifampicin(750mg)
Strip of 3 Tablet
(Inclusive of all taxes)
Anticox Z 450 mg/300 mg/750 mg Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.
Anticox Z 450 mg/300 mg/750 mg Tablet is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.
Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Mechanism of action — The antimicrobial activity of INH is selective for mycobacteria, likely due to its ability to inhibit mycolic acid synthesis, which interferes with cell wall synthesis, thereby producing a bactericidal effect
The mechanism of action for PZA is unknown. The parent compound enters the bacterium passively and is metabolized via pyrazinamidase (PZase) within the cytoplasm to pyrazinoic acid; pyrazinoic acid is the active form of the drug
Mechanism of action — Rifampin is thought to inhibit bacterial DNA-dependent RNA polymerase, which appears to occur as a result of drug binding in the polymerase subunit deep within the DNA/RNA channel, facilitating direct blocking of the elongating RNA. This effect is thought to be concentration related
Nausea
Vomiting
Fever
Rash
Dark colored urine
Sweating
Increased sputum production
Salivation
Watery eyes
Peripheral neuropathy (tingling and numbness of feet and hand)
Increased liver enzymes
Jaundice
Increased uric acid level in blood
Gout
Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug- induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology.
diabetes.
a type of joint disorder due to excess uric acid in the blood called gout.
porphyria.
alcoholism.
severe liver disease
hemolytic uremic syndrome, a condition that affects the kidney and the blood.
decreased blood-clotting from low vitamin K.
thrombotic thrombocytopenic purpura, a type of blood disorder.
liver problems.
abnormal liver function tests.
Anticox Z 450 mg/300 mg/750 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Anticox Z 450 mg/300 mg/750 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Anticox Z 450 mg/300 mg/750 mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Isoniazid is an antibiotic used in the treatment of mycobacterium tuberculosis infections. This activity describes the indications, action, and contraindications for isoniazid as a valuable agent in treating both active and latent tuberculosis infection
This medication is an anti-tuberculosis agent, prescribed for tuberculosis(TB). It works by killing or preventing the growth of certain bacteria that cause tuberculosis.
Tuberculosis: Rifampicin, used in combination with other active anti-tuberculosis drugs, is indicated in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifampicin is also effective against most atypical strains of mycobacteria
Do not chew, crush or break it. Anticox Z 450 mg/300 mg/750 mg Tablet is to be taken empty stomach.
Avoid Anticox Z 450 mg/300 mg/750 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Store below 30°C
If you miss a dose of Anticox Z 450 mg/300 mg/750 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Anticox Z 450 mg/300 mg/750 mg Tablet should be taken on an empty stomach but at the same time every day.
Do not skip any doses and finish the full course of treatment even if you feel better.
It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Anticox Z 450 mg/300 mg/750 mg Tablet affects you.
Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver.
Avoid taking hormone-based birth control methods as Anticox Z 450 mg/300 mg/750 mg Tablet may decrease their effectiveness.
Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Anticox Z 450 mg/300 mg/750 mg Tablet is to be taken empty stomach.
Avoid Anticox Z 450 mg/300 mg/750 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
