Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Aspirin (75mg) + Clopidogrel (75mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Antiplar Plus 75 mg/75 mg Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like low-fat diet, exercise and not smoking may help this medicine to work better.
Abdominal pain, indigestion, bruising, and nosebleeds are some common side effects of this medicine. This medicine increases your risk of bleeding, so it is important to be careful while shaving, cutting nails and using sharp objects. Usually, it is advisable to avoid alcohol intake while taking this medicine.
Before taking this medicine, tell your doctor if you have any liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Aspirin inhibits platelet cyclooxygenase by irreversible acetylation, thereby preventing the formation of thromboxane A2 which is a powerful stimulant of platelet aggregation. Clopidogrel, a thienopyridine, acts by inhibiting adenosine receptors, which inhibits the early step of platelet activation.
Aspirin is rapidly absorbed in the upper gastrointestinal (GI) tract and results in a measurable inhibition of platelet function within 60 minutes. This antiplatelet effect is associated with prolongation of the bleeding time and inhibition of TXA2-dependent platelet aggregation.
In the liver, approximately 15% of absorbed clopidogrel is metabolized by the cytochrome P450 (CYP) system to generate its active metabolite via a 2-step bioactivation process, whereas the rest 85% is hydrolyzed by carboxylesterase 1 (CES1) to an inactive carboxylic acid derivative.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Antiplar Plus
Abdominal pain
Bruise
Diarrhea
Gastrointestinal bleeding
Increased bleeding tendency
Nosebleeds
One of the inherent risks associated with using clopidogrel and aspirin is the risk for increased bleeding. If a patient is started on combination therapy, it is imperative to monitor for signs and symptoms of bleeding.
Contraindications: Aspirin is contraindicated in patients with known allergy to NSAIDs and in patients with asthma, rhinitis, and nasal polyps. It may cause anaphylaxis, laryngeal edema, severe urticaria, angioedema, or bronchospasm (asthma).
Antiplar Plus 75 mg/75 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Antiplar Plus 75 mg/75 mg Tablet.
Antiplar Plus 75 mg/75 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Aspirin and clopidogrel have complementary mechanisms of action to inhibit platelet function. Indications that have been studied include coronary artery disease (CAD), atherosclerotic ischemic stroke, and atrial fibrillation.
Dual therapy with aspirin and clopidogrel may prove effective at reduction of thromboembolic complications. However, the extent to which these two drugs interact may significantly increase the risk of bleeding in open surgery.
Do not chew, crush or break it. Antiplar Plus 75 mg/75 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Antiplar Plus 75 mg/75 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Antiplar Plus 75 mg/75 mg Tablet to lower your risk of heart attack and stroke.
Take it with food to avoid an upset stomach.
It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails or using sharp objects.
Let your doctor know you are taking Antiplar Plus 75 mg/75 mg Tablet before undergoing any surgical procedure.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Antiplar Plus 75 mg/75 mg Tablet is to be taken with food.
Q. Why have I been prescribed Antiplar Plus 75 mg/75 mg Tablet?
You may have been prescribed Antiplar Plus 75 mg/75 mg Tablet if you had a heart attack, were treated with stents in your coronary arteries, or had coronary artery bypass graft surgery (CABG).
Q. Is Antiplar Plus 75 mg/75 mg Tablet a blood thinner?
Yes, Antiplar Plus 75 mg/75 mg Tablet is a type of blood thinner. It works by preventing platelets (type of blood cells) from sticking together and forming clots. This action of Antiplar Plus 75 mg/75 mg Tablet helps in preventing conditions like heart attack or stroke in people with heart disease, who have recently suffered a heart attack or severe heart-related chest pain (unstable angina).
Q. How long do I need to take Antiplar Plus 75 mg/75 mg Tablet after stent insertion?
Your doctor will suggest the exact duration for which you may have to take Antiplar Plus 75 mg/75 mg Tablet. The duration will be decided after considering various factors like the illness you are being treated for, type of stent inserted, any episodes of bleeding experienced by you during treatment, etc. Usually, Antiplar Plus 75 mg/75 mg Tablet is prescribed for a minimum duration of 1 year. However, it is advised to follow your doctor's advice precisely to get maximum benefit of Antiplar Plus 75 mg/75 mg Tablet. Do not stop the medication on your own, consult your doctor first. Sudden discontinuation may increase the chances of clot formation in the stent, heart attack and can even lead to death.
Q. Can I drink alcohol while taking Antiplar Plus 75 mg/75 mg Tablet?
It is not advised to take alcohol while taking Antiplar Plus 75 mg/75 mg Tablet, as alcohol may increase your chance of stomach bleeding. As a result, you may vomit blood (which may be bright red blood or black/dark brown like coffee grounds) or you may have bloody or black tarry stools. Discuss with your doctor if you are not sure.
