Manufacturer: Aprica Pharmaceuticals Pvt Ltd
Salt Composition : Glimepiride(2mg), Metformin(500mg), Voglibose(0.2mg)
Strip of 15 Tablet Sr
(Inclusive of all taxes)
Apriglim-MV 2 Tablet SR should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Apriglim-MV 2 Tablet SR is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, edema (swelling), blurred vision, bone fracture, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
Apriglim-MV 2 Tablet SR is a combination of three antidiabetic medicines: Glimepiride, metformin and voglibose. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas to lower the blood glucose. Metformin is a biguanide which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Voglibose is an alpha-glucosidase inhibitor which prevents breakdown of complex sugars into simple sugars such as glucose. This prevents the blood glucose levels from rising to very high levels after meals.
Glimepiride is completely metabolized by oxidative biotransformation after either an IV or oral dose. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2). Cytochrome P450 2C9 has been shown to be involved in the biotransformation of glimepiride to M1.Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin.voglibose is poorly absorbed after oral administration. However, systematic adverse effects have been observed. Metabolism: the metabolism of voglibose in liver is negligible. Excretion: The renal excretion is negligible and plasma concentations after oral dose have been undetectable.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Apriglim-MV
Nausea
Diarrhea
Abdominal pain
Hypoglycemia (low blood glucose level)
Hypersensitivity to sulfonamide derivatives
Insulin dependent diabetes
Hypersensitivity to this drug
Acute myocardial infarction
Cardiovascular collapse
pregnant
Gastrointestinal obstruction
Diabetic ketoacidosis
Diabetic coma
Inflammatory bowel disease
Apriglim-MV 2 Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Apriglim-MV 2 Tablet SR.
Apriglim-MV 2 Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Glimepiride + Metformin + Voglibose is a combination of three antidiabetic medicines: Glimepiride, metformin and voglibose. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas to lower the blood glucose. Metformin is a biguanide which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Voglibose is an alpha-glucosidase inhibitor which prevents breakdown of complex sugars into simple sugars such as glucose. This prevents the blood glucose levels from rising to very high levels after meals.
Albuterol
Alcohol
Anabolic steroids
Androgens
Angiotensin converting enzyme inhibitors
Anti-diabetic drugs
Aspirin
Atenolol
Atypical antipsychotic medications
Barbiturates
Do not chew, crush or break it. Apriglim-MV 2 Tablet SR is to be taken empty stomach.
Store below 30°C
If you miss a dose of Apriglim-MV 2 Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Take it with food to lower your chance of having an upset stomach.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Carry a sugar source with you for immediate relief.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apriglim-MV 2 Tablet SR is to be taken empty stomach.
Q. What is Apriglim-MV 2 Tablet SR?
Apriglim-MV 2 Tablet SR is a combination of three medicines: Glimepiride, Metformin and Voglibose. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Voglibose is an alpha-glucosidase inhibitor which lowers the postprandial (after meals) glucose levels in the body. This combination is not indicated for the treatment of Type 1 DM.
Q. What are the possible side effects of Apriglim-MV 2 Tablet SR?
The use of Apriglim-MV 2 Tablet SR is associated with common side effects like hypoglycemia (low blood sugar level), nausea, diarrhea, altered taste, flatulence, stomach pain, headache, skin rash and respiratory tract infection.
Q. Are there any specific conditions in which Apriglim-MV 2 Tablet SR should not be taken?
The use of Apriglim-MV 2 Tablet SR should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine is also avoided in patients with moderate to severe kidney disease and in patients with inflammatory bowel disease, colonic ulcerations and underlying metabolic acidosis including diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am also taking Apriglim-MV 2 Tablet SR?
No, it is not safe to take Apriglim-MV 2 Tablet SR along with alcohol. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
Q. Can the use of Apriglim-MV 2 Tablet SR cause hypoglycemia?
Yes, the use of Apriglim-MV 2 Tablet SR can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.
Q. What are the instructions for the storage and disposal of Apriglim-MV 2 Tablet SR?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
