Apristar 125 mg / 80 mg Capsule (3'S)

Manufacturer: Lupin Ltd

Salt Composition : Aprepitant(125mg), Aprepitant(80mg)


Apristar 125 mg/80 mg Capsule is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are constipation, indigestion, headache, tiredness, loss of appetite, and hiccups. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine can cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding.


Basic Information

Mechanism Of Action

Apristar 125 mg/80 mg Capsule is a combination of two different doses of Aprepitant. It works by blocking the action of a chemical messenger in the brain that may cause nausea and vomiting during treatment with anti-cancer medicines.


Pharmacokinets

Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV).Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV).

Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Apristar

Constipation

Indigestion

Headache

Tiredness

Loss of appetite

Hiccup

Increased liver enzymes

Contra Indications

Kidney Disease

Allergy

Low Blood Pressure

Liver Disease

Pregnancy Related Information

Information regarding the use of Apristar 125 mg/80 mg Capsule during pregnancy is not available. Please consult your doctor.


Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Apristar 125 mg/80 mg Capsule. Please consult your doctor.


Breast Feeding Related Information

Apristar 125 mg/80 mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.


Children Related Information

Use with caution

Below 9years: Contraindicated


Indications

Aprepitant + Aprepitant is a combination of two different doses of Aprepitant. It works by blocking the action of a chemical messenger in the brain that may cause nausea and vomiting during treatment with anti-cancer medicines.


Interactions

Benzodiazepines

Carbamazepine

Clarithromycin

Corticosteroids

Diltiazem

Hormonal contraception

Itraconazole

Ketoconazole

Nefazodone

Nelfinavir

Typical Dosage

Apristar 125 mg/80 mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

Storage Requirements

Store below 30°C


Effects Of Missed Dosage

If you miss a dose of Apristar 125 mg/80 mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.


Effects Of Overdose

Consult a doctor before taking any medicines.

Expert Advice

Apristar 125 mg/80 mg Capsule is taken alongside other medicines to help stop sickness (nausea and vomiting) after chemotherapy.

Even if you do not feel like eating or drinking, try to sip water regularly to prevent you from becoming lacking in fluid in the body (dehydrated).

If you are taking any contraceptive 'pill' at the same time as this medicine, the effectiveness of the 'pill' can be reduced if you have a bout of being sick (vomiting) which lasts for more than 24 hours. In such a case, ask your doctor for additional contraceptive precautions.

How To Use

Take this medicine in the dose and duration as advised by your doctor. Apristar 125 mg/80 mg Capsule may be taken with or without food, but it is better to take it at a fixed time.