Manufacturer: Alkem Laboratories Ltd
Salt Composition : Aprotinin(1.4mg)
Aprogen 1.4mg Infusion must be administered under the supervision of a healthcare professional. Do not self-administer this medicine at home. You should not use it if you have any known allergies from this injection.
It may cause injection site reactions such as pain, swelling, and redness in some people. Let your doctor know if they bother you. Additionally, inform your doctor if you have undergone any cardiac surgery or you are suffering from any liver disease.
Aprotinin is a competitive inhibitor of several serine proteases, specifically trypsin, chymotrypsin and plasmin at a concentration of about 125,000 IU/ml, and kallikrein at 300,000 IU/ml. Its action on kallikrein leads to the inhibition of the formation of factor XIIa.
Aprotinin is slowly degraded by lysosomal enzymes. Following a single IV dose of radiolabelled aprotinin, approximately 25-40% of the radioactivity is excreted in the urine over 48 hours. After a 30 minute infusion of 1 million KIU, about 2% is excreted as unchanged drug.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aprogen
Injection site reactions (pain, swelling, redness)
Contraindications to aprotinin include hypersensitivity to the active substance. Patients with a positive aprotinin-specific IgG antibody test are at an increased risk of anaphylactic reaction when treated with aprotinin, providing an absolute contraindication.
Aprogen 1.4mg Infusion is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is not known whether it is safe to consume alcohol with Aprogen 1.4mg Infusion. Please consult your doctor.
Aprogen 1.4mg Infusion is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Aprotinin is indicated for prophylactic use to reduce perioperative blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass in the course of coronary artery bypass graft surgery who are at an increased risk for blood loss and blood transfusion.
Acetylcholine The risk or severity of adverse effects can be increased when Aprotinin is combined with Acetylcholine.
Aclidinium Aprotinin may increase the neuromuscular blocking activities of Aclidinium.
Kindly do not self-administer.
Store below 30°C
If you miss a dose of Aprogen 1.4mg Infusion, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Aprogen 1.4mg Infusion helps prevent or reduce heavy bleeding post surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
It is given as a slow injection into a vein.
Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
Your doctor may monitor your vision regularly while you are taking this medicine.
Inform your doctor if you have a history of kidney or liver disease.
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
Q. What Aprogen 1.4mg Infusion is and what it is used for?
Aprogen 1.4mg Infusion belongs to a group of medicines called antifibrinolytics, i.e. medicines to prevent blood loss.
Q. How is Aprogen 1.4mg Infusion given?
This injection will usually be given to you lying down by slow injection or infusion (through ‘a drip’) through a catheter into a larger vein in your body.
Q. Can Aprogen 1.4mg Infusion be given to children?
This injection should be avoided in children since its safety and efficacy in children below the age of 18 years have not been established. Consult your doctor for more advice.
Q. What other medications should be avoided while taking Aprogen 1.4mg Infusion?
It is advisable to avoid taking any other anti-fibrinolytic and antibiotics while taking Aprogen 1.4mg Infusion. Inform your doctor before the start of the treatment if you are taking any of these.
