Manufacturer: RKG Pharma
Salt Composition : Sodium Valproate(133mg), Valproic Acid(58mg)
Strip of 10 Tablet Cr
(Inclusive of all taxes)
Arkaval Tablet CR 133mg/58mg should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, swelling of gums, headache, sleepiness, tremor, hair loss and liver injury. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.
Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Arkaval Tablet CR 133mg/58mg can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.
Arkaval Tablet CR 133mg/58mg is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
Sodium valproate (VPA) was first marketed in the United States in 1978. In this pilot study of pharmacokinetics and toxicity, VPA was added to the treatment regimens of 20 patients (10 adults and 10 children) with intractable seizures. The drug was absorbed and excreted rapidly; the mean half-life was 9.6 hours.Valproic acid exhibits its pharmacologic effects in a couple of ways, such as by acting on GABA (γ aminobutyric acid) levels in the CNS, blocking voltage-gated ion channels, and inhibiting histone deacetylase.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Arkaval
Nausea
Vomiting
Weight gain
Loss of appetite
Gum swelling
Headache
Sleepiness
Tremors
Hair loss
Liver injury
Allergic reactions
Alpers' disease
Hypersensitivity
Lactation
Liver disease
Liver impairment
Pregnancy
Urea cycle disorder
Arkaval Tablet CR 133mg/58mg is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Arkaval Tablet CR 133mg/58mg.
Arkaval Tablet CR 133mg/58mg is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Use with caution
Below 9years: Contraindicated
Sodium Valproate + Valproic Acid is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
SODIUM VALPROATE+VALPROIC ACID may have interaction with pain killers (aspirin), anti-epileptics (phenobarbital, primidone, phenytoin, carbamazepine, lamotrigine, felbamate), anti-HIV (zidovudine), anti-depressant (amitriptyline, sertraline), anti-psychotic (quetiapine, olanzapine, risperidone), hormone (levonorgestrel), anti-malarial (mefloquine), antacid (cimetidine), antibiotics (imipenem, meropenem, erythromycin), bile-acid sequestrant (cholestyramine), benzodiazepine (clonazepam, diazepam).
Do not chew, crush or break it. Arkaval Tablet CR 133mg/58mg is to be taken with food.
Store below 30°C
If you miss a dose of Arkaval Tablet CR 133mg/58mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Arkaval Tablet CR 133mg/58mg for treatment and prevention of seizures.
Take it at the same time every day to maintain consistent levels in your body.
Do not drive or do anything that requires mental focus until you know how Arkaval Tablet CR 133mg/58mg affects you.
Avoid consuming alcohol when taking Arkaval Tablet CR 133mg/58mg, as it may cause excessive sleepiness or drowsiness.
Monitor your weight during the treatment as Arkaval Tablet CR 133mg/58mg can cause weight gain.
Your doctor may monitor Arkaval Tablet CR 133mg/58mg level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
Do not take Arkaval Tablet CR 133mg/58mg if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arkaval Tablet CR 133mg/58mg is to be taken with food.
Q. Can the use of Arkaval Tablet CR 133mg/58mg cause sleepiness or drowsiness?
Yes, Arkaval Tablet CR 133mg/58mg may make you feel drowsy or sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities. Inform your doctor if you experience such an episode while taking this medicine.
Q. Can I drink alcohol while taking Arkaval Tablet CR 133mg/58mg?
No, avoid drinking alcohol while taking Arkaval Tablet CR 133mg/58mg. Drinking alcohol will increase the side effects caused by Arkaval Tablet CR 133mg/58mg.
Q. Can Arkaval Tablet CR 133mg/58mg be stopped when epilepsy symptoms are relieved?
No, Arkaval Tablet CR 133mg/58mg should be continued as advised by the doctor. Stopping Arkaval Tablet CR 133mg/58mg suddenly may cause the symptoms to reappear that too with increased frequency. If any problems are experienced due to Arkaval Tablet CR 133mg/58mg, consult the doctor for re-evaluation.
Q. Will a higher than the recommended dose of Arkaval Tablet CR 133mg/58mg be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. If the recommended doses do not relieve your symptoms or there is an increased severity of your symptoms, please consult your doctor.
Q. What are the instructions for the storage and disposal of Arkaval Tablet CR 133mg/58mg?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
