Manufacturer: Alkem Laboratories Ltd
Salt Composition : Arsenic Trioxide(10mg)
Arsikem 10mg Injection is given as an injection into veins under the supervision of a doctor, with regular monitoring of blood pressure. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, increased heart rate, rash, and fatigue. It might cause increased blood glucose level, inform your doctor if you experience extreme thirst, hunger or frequent urination and blurred vision. Regular blood tests are required to monitor your blood calcium, potassium, and creatinine, before and during treatment with this medicine. You will also be monitored for ECG before and during the treatment.
Before taking it, tell your doctor if have heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Arsenic apparently affects numerous intracellular signal transduction pathways and causes many alterations in cellular function. These actions of arsenic may result in the induction of apoptosis, the inhibition of growth and angiogenesis, and the promotion of differentiation.
Arsenic trioxide is a chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy. Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Arsikem
Breathlessness
Nausea
Vomiting
Increased heart rate
Rash
Decreased potassium level in blood
Paresthesia (tingling or pricking sensation)
Dizziness
Injection site pain
Increased liver enzymes
Increased glucose level in blood
Fever
Diarrhea
Fatigue
Itching
deficiency in thiamine or vitamin B1.
low amount of magnesium in the blood.
high levels of potassium in the blood.
low amount of potassium in the blood.
complete heart block.
torsades de pointes, a type of abnormal heart rhythm.
prolonged QT interval on EKG.
chronic heart failure.
Arsikem 10mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Arsikem 10mg Injection. Please consult your doctor.
Information regarding the use of Arsikem 10mg Injection during breastfeeding is not available. Please consult your doctor.
Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.
artemether/lumefantrine.
cisapride.
dronedarone.
epinephrine racemic.
erythromycin base.
erythromycin ethylsuccinate.
erythromycin lactobionate.
erythromycin stearate.
Kindly do not self administer.
Store below 30°C
Arsikem 10mg Injection is given as an injection into the veins with continuous monitoring of blood pressure.
You may be monitored with ECG before and after starting the treatment.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need regular blood tests to monitor the levels of calcium, potassium, and creatinine in the blood.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Are there any serious side effects of Arsikem 10mg Injection?
Arsikem 10mg Injection can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 day to 2 months after you start taking this medicine. Seek medical help right away if you develop symptoms like chest pain, trouble breathing, dizziness, cough, swelling, fever, rapid weight gain, or decreased urination.
Q. What should I inform my doctor before taking Arsikem 10mg Injection?
Before taking Arsikem 10mg Injection you must inform your doctor if you have heart problems, low potassium or magnesium in blood, kidney, or liver disease.
Q. Are there any tests needed during the treatment with Arsikem 10mg Injection?
Your doctor will prescribe tests to check the amount of potassium, magnesium, calcium, and creatinine in your blood before your first dose of Arsikem 10mg Injection. You will also be prescribed an electrical recording of the heart (electrocardiogram ECG) performed before your first dose.
Q. Can I use Arsikem 10mg Injection during pregnancy?
No, this medicine should not be used during pregnancy. After the last dose of the Arsikem 10mg Injection, women should continue using non-hormonal contraceptives for at least 6 months, while men should continue for at least 3 months.
