Arthrin MR 100 mg / 500 mg / 250 mg Tablet (10'S)

Manufacturer: Elan Pharma India Pvt Ltd

Salt Composition : Aceclofenac(100mg), Paracetamol(500mg), Chlorzoxazone(250mg)

Prescription Required: Consult the Doctor & Get Your ePrescription

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₹34.47

Strip of 10 Tablet

(Inclusive of all taxes)

Arthrin MR 100 mg/500 mg/250 mg Tablet is a combination medicine that helps in relieving muscular pain. It works by blocking the release of certain chemical messengers that cause pain, inflammation, and fever. This improves the movement of muscles and provides relief from pain and discomfort.
Arthrin MR 100 mg/500 mg/250 mg Tablet can be taken with or without food. The dose and duration will depend on the severity of your condition. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it.
Using this medicine may cause common side effects such as nausea, vomiting, heartburn, stomach pain, diarrhea, and loss of appetite. If these persist or get worse, let your doctor know. In general, you should try to use the smallest amount necessary to control your symptoms.
Before using the medicine, you should tell your doctor if you have any other medical conditions or disorders. To make sure it is safe, you should let your doctor know all the other medicines you are taking. Also, tell your doctor if you have any problems with the liver or kidneys. You should avoid the consumption of alcohol while on treatment with this medicine. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Basic Information

Mechanism Of Action

Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins

Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury

Pharmacokinets

Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins. After oral administration, aceclofenac is rapidly and completely absorbed as unchanged drug. Peak plasma concentrations are reached approximately 1.25 to 3.00 hours following ingestion. Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver (90-95%) and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol.

Analysis of plasma samples indicated a rapid absorption and rapid elimination of chlorzoxazone. Average values of the elimination half-life and plasma clearance were 1.12 +/- 0.48 hr and 148.0 +/- 39.9 ml/min, respectively

Side Effects

Nausea

Vomiting

Heartburn

Stomach pain

Diarrhea

Loss of appetite

Tiredness

Sleepiness

Contra Indications

If you are allergic to paracetamol and aceclofenac. If you have a history of ulcer or bleeding in the stomach or any part of your digestive tract. If you have experienced an allergic reaction due

Chlorzoxazone is contraindicated in any patient with a known or suspected intolerance or hypersensitivity to the drug or any of the product ingredients. If a sensitivity reaction such as urticaria, pruritus, or skin erythema occurs, discontinue chlorzoxazone. Angioedema or anaphylactic reactions are extremely rare

Pregnancy Related Information

Information regarding the use of Arthrin MR 100 mg/500 mg/250 mg Tablet during pregnancy is not available. Please consult your doctor.

Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Arthrin MR 100 mg/500 mg/250 mg Tablet. Please consult your doctor.

Breast Feeding Related Information

Information regarding the use of Arthrin MR 100 mg/500 mg/250 mg Tablet during breastfeeding is not available. Please consult your doctor.

Indications

Aceclofenac+Paracetamol is used for pain relief. Aceclofenac + Paracetamol is a combination of two medicines: Aceclofenac and Paracetamol. These medicines work by blocking the action of chemical messengers responsible for pain, fever and inflammation

Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties

Interactions

ACECLOFENAC+PARACETAMOL interact with cholesterol lowering drugs (cholestyramine), charcoal, medicine to stop vomiting (domperidone, metochlopramide), alcohol, anti HIV drug (zidovudine), blood thinner (warfarin), blood pressure lowering medicine, anti cancer or anti arthritis drug (methotrexate)

Buprenorphine Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.

Bupropion The metabolism of Chlorzoxazone can be decreased when combined with Bupropion.

Typical Dosage

Swallow it as a whole. Do not chew, crush or break it. Arthrin MR 100 mg/500 mg/250 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Storage Requirements

Store below 30°C

Effects Of Missed Dosage

If you miss a dose of Arthrin MR 100 mg/500 mg/250 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Effects Of Overdose

Consult a doctor before taking any medicines.

Expert Advice

Avoid consuming alcohol when taking Arthrin MR 100 mg/500 mg/250 mg Tablet as it may cause excessive drowsiness and increase the risk of liver damage.

Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Arthrin MR 100 mg/500 mg/250 mg Tablet.

Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.

How To Use

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arthrin MR 100 mg/500 mg/250 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

FAQs

Q. What is Arthrin MR 100 mg/500 mg/250 mg Tablet?

Arthrin MR 100 mg/500 mg/250 mg Tablet is a combination of three medicines: Aceclofenac, Paracetamol and Chlorzoxazone. This medicine helps in relieving muscle pain by relaxing the affected muscles. It relieves pain caused due to muscle spasm, cramp or injury. It also lowers certain chemical substances in the body that cause pain.

Q. What can I do along with Arthrin MR 100 mg/500 mg/250 mg Tablet to reduce muscle pain?

If you are suffering from muscle pain due to muscle injury or overuse, you should take rest. Taking rest will help you avoid any further injury and help you recover efficiently. Make sure that you take plenty of sleep and try to reduce stress. Applying ice pack to the affected area may help in relieving pain and inflammation. If your muscle pain is due to some other disease, follow the advice of your doctor.

Q. Can I get addicted to Arthrin MR 100 mg/500 mg/250 mg Tablet?

No, there are no reports of any patient getting addicted to Arthrin MR 100 mg/500 mg/250 mg Tablet.

Q. Can I stop taking Arthrin MR 100 mg/500 mg/250 mg Tablet when my pain is relieved?

Arthrin MR 100 mg/500 mg/250 mg Tablet is usually used for short term and can be discontinued when your pain is relieved. However, Arthrin MR 100 mg/500 mg/250 mg Tablet should be continued if you are advised by your doctor to do so.