Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Asparaginase(5000IU)
Asginase 5000IU Injection is given as an injection by the doctor, but try to have it the same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effect of this medicine includes breathlessness, rash, vomiting, angioedema (swelling of deeper layers of skin), and nausea. It might cause increased blood sugar levels, hence regular blood tests are required to monitor your blood sugar levels, response to the therapy, and any side effects. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.
This medicine may lower your body's resistance and increase susceptibility to infections. Infections can sometimes be life-threatening. It is important to use effective contraception to avoid getting pregnant or fathering a child during treatment. Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.
Asparaginase is widely used in chemotherapeutic regimens for the treatment of acute lymphoblastic leukemia (ALL) and has led to a substantial improvement in cure rates, especially in children. Optimal therapeutic effects depend on a complete and sustained depletion of serum asparagine.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Asginase
Breathlessness
Rash
Vomiting
Angioedema (swelling of deeper layers of skin)
Edema (swelling)
Nausea
Fatigue
Increased liver enzymes
Diarrhea
Decreased blood pressure
Flushing (sense of warmth in the face, ears, neck and trunk)
Low albumin level in blood
Increased glucose level in blood
Hives
diabetes.
increased uric acid in the body resulting in kidney disease.
a type of joint disorder due to excess uric acid in the blood called gout.
anemia.
an increased risk of bleeding.
low levels of white blood cells.
obstruction of a blood vessel by a blood clot.
bleeding.
Asginase 5000IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Asginase 5000IU Injection. Please consult your doctor.
Asginase 5000IU Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Acute lymphoblastic leukemia.
Acute myeloid leukemia.
Non-Hodgkin lymphoma.
coagulation abnormalities/bleeding.
pancreatic dysfunction.
hepatic dysfunction.
hyperglycemia.
myelosuppression.
mental status changes.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
Asginase 5000IU Injection is given as an injection into the veins, muscles or under the skin by the healthcare provider.
It is advisable to drink plenty of fluids and stay hydrated while taking this medication.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, liver function and kidney function during treatment.
It can cause an increase in blood sugar levels. Hence, monitor your blood sugar level regularly.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. When should I call my doctor right away?
Get medical help right away if you have signs of allergic reaction such as difficulty breathing, rash, hives, itching, and blisters. Also, let your doctor know if you experience severe headache, chest pain, severe abdominal pain, and swelling in various parts of the body.
Q. Can Asginase 5000IU Injection damage my liver?
Asginase 5000IU Injection may affect the liver and cause serious or even life-threatening damage to the liver. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).
Q. I am experiencing nausea and extreme tiredness. Is this due to Asginase 5000IU Injection?
Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.
Q. How to get relief from diarrhea while on treatment with Asginase 5000IU Injection?
Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.
