Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Maraviroc(150mg)
Axentri 150mg Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow the instructions carefully, for all the medicines that you are given. It may be taken with or without food, preferably at a fixed time. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop. Before taking it, tell your doctor if you have any skin problems or liver or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.
Maraviroc is an entry inhibitor and works by blocking HIV from entering human cells. Specifically maraviroc is a selective, slowly reversible, small molecule antagonist of the interaction between human CCR5 and HIV-1 gp120.
Pharmacokinetics. Maraviroc is rapidly absorbed with an absolute bioavailability of 33% following a 300mg dose. The peak plasma concentrations are reached in 0.5-4 hours following a single dose. Maraviroc is primarily metabolized by cytochrome P450 systems, using CYP3A4 as the major enzyme.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Axentri
Nausea
Rash
Anemia (low number of red blood cells)
Insomnia (difficulty in sleeping)
Weakness
Increased liver enzymes
Abdominal pain
Flatulence
Loss of appetite
Depression
an infection.
a heart attack.
coronary artery disease.
a low supply of oxygen rich blood to the heart.
orthostatic hypotension, a form of low blood pressure.
damage to the liver and inflammation.
liver problems.
a patient who is producing milk and breastfeeding.
Axentri 150mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Caution is advised when consuming alcohol with Axentri 150mg Tablet. Please consult your doctor.
Axentri 150mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Maraviroc is indicated in combination with other antiretroviral agents for the treatment of CCR5-tropic HIV-1 infection in adults and pediatric patients weighing at least 2kg. It is not recommended in patients with dual/mixed- or CXCR4-tropic HIV-1.
There are 3 disease interactions with maraviroc which include:
hepatotoxicity/liver impairment.
renal impairment.
cardiovascular disease.
Do not chew, crush or break it. Axentri 150mg Tablet may be taken with or without food
Store below 30°C
If you miss a dose of Axentri 150mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Axentri 150mg Tablet is given to slow the progress of HIV infection.
Although treatment with Axentri 150mg Tablet can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is therefore important to use condoms.
If you develop any infection soon after taking Axentri 150mg Tablet, inform your doctor. As a result of taking Axentri 150mg Tablet, your immune system may start fighting an infection that was present before you started the treatment, but you might not be aware of it.
It is common for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made. If you have any feelings of depression it is advisable to speak with your doctor.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Axentri 150mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
