Manufacturer: Intas Pharmaceuticals Ltd
Salt Composition : Azacitidine(100mg)
Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding.
At low doses, azacitidine inhibits DNA methyltransferase by formation of covalent bonds between DNA-cytosine methyltransferase and DNA containing 5-azacytosine, resulting in DNA hypomethylation. Decitabine is a deoxyribonucleoside that can only be incorporated in DNA.
Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine may induce antineoplastic activity by inhibition of DNA methyltransferase at low doses and cytotoxicity through incorporation into RNA and DNA at high doses.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Azadine
Injection site reactions (pain, swelling, redness)
Vomiting
Weakness
Nausea
Decreased potassium level in blood
Bruise
Fever
Chills
Diarrhea
Constipation
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
severe liver disease.
decreased kidney function.
abnormal liver function tests.
pregnancy.
a patient who is producing milk and breastfeeding.
advanced liver cancer.
Azadine Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Azadine Injection. Please consult your doctor.
Azadine Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Azacitidine injection is used to treat patients with French-American-British (FAB) myelodysplastic syndrome (bone marrow problem) subtypes, including refractory anemia or chronic leukemia. This medicine is also used to treat juvenile myelomonocytic leukemia (JMML).
There are 4 disease interactions with azacitidine which include:
hepatic tumors.
hepatic impairment.
renal impairment.
anemia.
Kindly do not self administer.
Store below 30°C
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Azadine Injection a vesicant?
Azadine Injection is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected Azadine Injection into the surrounding tissues from the site of administration) when injected
Q. Does Azadine Injection cause hair loss?
No, Azadine Injection is not known to cause hair los
Q. Is Azadine Injection chemotherapy?
Yes. Azadine Injection is chemotherapy and a cytotoxic drug used in the treatment of various cancers. It is toxic to cancer cells and interferes with the cell's DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect)
Q. Is Azadine Injection a cytotoxic drug?
Yes. Azadine Injection is a cytotoxic drug.
