Manufacturer: Cipla Ltd
Salt Composition : Sacubitril(24mg), Valsartan(26mg)
Azmarda 50mg Tablet can be taken with or without food but is best taken at the same time(s) each day. Swallow it as a whole with water. Your dose, and how often you take it, will be decided by your doctor and may change depending on how well you respond to the medicine. Keep taking the tablets regularly, as they have been prescribed, and try not to miss doses to get the most benefit. Do not stop taking them, even if you are feeling well. These tablets are preventing future harm.
Sacubitril lowers blood pressure by causing blood vessel relaxation, excretion of sodium through urine and increasing urination. Valsartan works by relaxation of blood vessels so that the heart pumps blood more easily through blood vessels to the body.
Absorption of sacubitril/valsartan and conversion of sacubitril (prodrug) to sacubitrilat (neprilysin inhibitor) was rapid with maximum plasma concentrations of sacubitril, sacubitrilat, and valsartan (angiotensin receptor blocker) reaching within 0.5, 1.5-2.0, and 2.0-3.0 h, respectively.In healthy subjects, following oral administration, valsartan is absorbed and distributed rapidly. After administration of 80 mg, the maximum valsartan concentration is reached in about 2 h, the half-life is 6–9 h, and 24-h urinary recovery of unchanged drug is ≤ 10% of the administered dose (5).
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Azmarda
Dizziness
Increased potassium level in blood
Fatigue
Hypotension (low blood pressure)
Hypersensitivity to Azmarda Tablet is a contraindication. In addition, Azmarda Tablet should not be used if you have the following conditions:
Biliary obstruction
Breastfeeding
Dehydrated due to sickness, diarrhea or use of diuretics
History of swelling of eyes and lips or any heart disease
Hypersensitivity
Pregnant
Primary hyperaldosteronism
Severe renal or hepatic impairment
Azmarda 50mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Azmarda 50mg Tablet.
Azmarda 50mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Sacubitril/valsartan is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association [NYHA] class II to IV) and reduced ejection fraction.
If you use other drugs or over the counter products at the same time, the effects of Azmarda Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Azmarda Tablet may interact with the following drugs and products:
Aliskiren
Benazepril
Birth control pills
Drospirenone
Lisinopril
Lithium
Potassium glycerophosphate
Do not chew, crush or break it. Azmarda 50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Azmarda 50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Azmarda 50mg Tablet for the treatment of of long-lasting (chronic) heart failure.
You should continue to stay active (light walking, stretching) and eat a healthy, low sodium diet along with taking this medication.
To reduce the chances of feeling dizzy, rise slowly if you have been sitting or lying down.
It may cause the level of potassium in your blood to go up. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Inform your doctor if you have a history of liver or kidney diseases.
Do not take Azmarda 50mg Tablet if you are pregnant or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azmarda 50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Who should avoid taking Azmarda 50mg Tablet?
Patients who are allergic to any of its components should avoid Azmarda 50mg Tablet. Also, those who are allergic to the use of ACE inhibitors or ARBs should avoid using this medicine. It should not be used along with other antihypertensive medicines like ACE inhibitors or ARBs. Do not take it for at least 36 hours before or after you take an ACE inhibitor medicine. If you are not sure, consult your doctor.
Q. What should I tell my doctor before taking Azmarda 50mg Tablet?
Tell your doctor about all of your medical conditions, including liver or kidney disease, history of facial swelling (angioedema). Inform him if you are pregnant or are breastfeeding. Also, let your doctor know about all medicines you are taking, especially potassium supplements or its medicine salt, painkillers, blood pressure or heart failure medicines (such as ACE inhibitor, ARBs or Aliskiren).
Q. Can I use Azmarda 50mg Tablet in pregnancy?
No, Azmarda 50mg Tablet should be avoided in pregnancy. Its use can cause injury or even endanger the life of the baby. If you become pregnant while using Azmarda 50mg Tablet, stop using it and contact your doctor immediately.
Q. How would I know if I have high potassium levels?
Your doctor will check your blood potassium levels periodically to detect high potassium levels (hyperkalemia). Make sure that you do not miss any scheduled appointments with the doctor.
