Manufacturer: Glenmark Pharmaceuticals Ltd
Salt Composition : Bortezomib(3.5mg)
Bortrac Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Bortrac Injection is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.
The pharmacokinetic profile of intravenous bortezomib is characterized by a two-compartment model with a rapid initial distribution phase followed by a longer elimination phase and a large volume of distribution. Bortezomib is available for subcutaneous and intravenous administration.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Bortrac
Low blood platelets
Fatigue
Peripheral neuropathy (tingling and numbness of feet and hand)
Psychiatric disturbances
Nausea
Vomiting
Loss of appetite
Fever
Anemia (low number of red blood cells)
Diarrhea
Decreased appetite
Decreased white blood cell count (neutrophils)
Constipation
diabetes
dehydration
decreased blood platelets
low levels of a type of white blood cell called neutrophils
a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
pulmonary hypertension
chronic heart failure
thrombotic thrombocytopenic purpura, a type of blood disorder
orthostatic hypotension, a form of low blood pressure
low blood pressure
pneumonia
a type of inflammation of the lung called interstitial pneumonitis
acute respiratory distress syndrome, a type of lung disorder
blocked bowels with decreased peristaltic movement
liver problems
abnormal liver function tests
pregnancy
a patient who is producing milk and breastfeeding
a type of brain disorder called posterior reversible encephalopathy syndrome
Child-Pugh class B liver impairment
Child-Pugh class C liver impairment
Bortrac Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Bortrac Injection may cause excessive drowsiness with alcohol.
Bortrac Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Use with caution
Below 9years: Contraindicated
Bortezomib is indicated for the treatment of adult patients with multiple myeloma or mantle cell lymphoma.
BORTEZOMIB interacts with antifungal medication (ketoconazole), HIV medication (ritonavir), antibiotic medication (rifampicin), epilepsy medications (carbamazepine, phenytoin or phenobarbital), depression medication (St. John’s Wort), and oral antidiabetics.
Kindly do not self administer.
Store below 25°C
If you miss a dose of Bortrac Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Bortrac Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. When should I call my doctor right away?
Get medical help right away if you have muscle cramping, muscle weakness, confusion, visual loss or disturbances, blindness, seizures, headaches, shortness of breath, swelling of your feet or changes in your heartbeat, high blood pressure, tiredness, fainting, coughing and breathing difficulties or tightness in the chest.
Q. How will you know that Bortrac Injection is working?
Keep taking this medicine exactly as directed until your doctor tells you to stop. Regular scans will reveal whether your tumor is responding to the treatment. Your doctor will determine when those scans should be scheduled.
Q. What precautions should I take to reduce the chances of getting infected during treatment with Bortrac Injection?
Since Bortrac Injection lowers the number of white blood cells and platelets in your blood, it puts you at risk of getting an infection or bleeding. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get a fever, chills, cough; be careful not to cut yourself when you are using sharp objects such as a razor or nail cutters, and use a toothbrush with soft bristles to prevent bleeding from gums.
Q. Can Bortrac Injection be used during pregnancy?
No, this medicine should not be used during pregnancy as it can harm your unborn baby. Avoid getting pregnant and use an effective method of birth control during your treatment and for at least 3 months after the last dose of Bortrac Injection.
Q. Can Bortrac Injection affect my lungs? What should I do?
Yes, this medicine might cause potentially fatal problems in your lung. If you feel severe shortness of breath, confusion, dry cough, dizziness, or extreme tiredness, talk to your doctor right away.
Q. Does Bortrac Injection cause hair loss?
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Q. Are there any precautions for tingling sensation and numbness in my arms and legs?
This medicine causes tingling, numbness, pain, or burning sensation in your arms or legs. Be careful when moving around, as the numbness may make it harder to walk, feel your hands or feet, or increase your risk of falls. Talk to your doctor if you feel these symptoms. You may need to change your dose or schedule.
Q. I have noticed some changes in my skin after taking Bortrac Injection? What should I do?
Use a moisturizer to get relief from rashes, dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen with (SPF more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water bath and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.
Q. How to relieve constipation during the treatment?
To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.
Q. I am experiencing nausea and extreme tiredness. Is this due to Bortrac Injection?
Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.
Q. I am noticing a change in my taste. How shall I improve my taste?
You may experience a metallic taste or find that food has no taste at all. You may dislike foods or beverages that you liked before receiving cancer treatment. Rinse your mouth with a solution of salt and bicarbonate of soda before mealtimes to neutralize the bad taste in your mouth. You can also add extra flavor or seasonings to your food.
