Manufacturer: Celon Laboratories Ltd
Salt Composition : Dacarbazine(200mg)
Celdaz 200mg Injection is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The exact mechanism of action of dacarbazine is not known.
Its major action is through alkylation. Dacarbazine is activated by liver microsomal enzymes to form 5-(3-monomethyl-1-triazenyl)-1H-imidazole-4-carboxamide (MTIC).
It inhibits DNA and RNA synthesis by forming carbonium ions.
The pharmacokinetics of dacarbazine (DTIC) and its main metabolite 5-aminoimidazole-4-carboxamide (AIC) have been studied in eight patients with malignant melanoma or sarcoma receiving 2.65--6.85 mg DTIC/kg body weight by intravenous bolus injection or by continuous 0.5--6-h infusions on 5 consecutive days.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Celdaz
Nausea
Vomiting
Injection site pain
Decreased white blood cell count
Loss of appetite
decreased function of bone marrow.
anemia.
decreased blood platelets.
low levels of white blood cells.
a blood clot in a vein of the liver.
liver tissue death.
liver problems.
decreased kidney function.
Celdaz 200mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Caution is advised when consuming alcohol with Celdaz 200mg Injection. Please consult your doctor.
Celdaz 200mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Dacarbazine is indicated for the treatment of patients with metastasised malignant melanoma. Further indications for dacarbazine as part of a combination chemotherapy are: advanced Hodgkin's disease, advanced adult soft tissue sarcomas (except mesothelioma, Kaposi sarcoma).
infections.
hepatic dysfunction.
myelosuppression.
renal dysfunction.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Celdaz 200mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Celdaz 200mg Injection is given as an injection into veins under the supervision of a doctor.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How is Celdaz 200mg Injection administered?
Celdaz 200mg Injection is administered as infusion or injection. Absorption by mouth is slow and varies, therefore, intravenous (given through vein) infusion or injection administration is preferred.
Q. Is Celdaz 200mg Injection a vesicant?
Celdaz 200mg Injection is a potent vesicant (it is corrosive), and it should be carefully administered to avoid the risk of extravasation (leaking into the tissues).
Q. What is Celdaz 200mg Injection used for?
Celdaz 200mg Injection is used to treat skin cancer that has spread to other parts of the body (malignant melanoma), cancer of the white blood cell (Hodgkin's lymphoma) and advanced adult soft tissue sarcomas (cancer of soft tissues such as muscles, tendons, fat, and blood vessels).
Q. How effective is Celdaz 200mg Injection?
Celdaz 200mg Injection is effective if taken at recommended dosage and duration as advised by your doctor.
Q. Does Celdaz 200mg Injection cause hair loss?
Yes, hair loss is a common side effect of Celdaz 200mg Injection.
