Manufacturer: Alkem Laboratories Ltd
Salt Composition : Gemcitabine(1000mg)
Celgem 1000mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most important mechanism of action of gemcitabine is inhibition of DNA synthesis (Huang et al., 1991). When dFdCTP is incorporated into DNA, a single deoxynucleotide is incorporated afterwards, preventing chain elongation
Gemcitabine is a hydrophilic molecule, and three nucleoside transporters mediate most of its uptake into cells: SLC29A1 SLC28A1, and SLC28A3. Gemcitabine is also a pro-drug that requires serial phosphorylation by multiple kinases to become pharmacologically active.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Celgem
Nausea
Vomiting
Loss of appetite
Hair loss
Low blood platelets
Allergic reaction
Breathlessness
Decreased white blood cell count
Increased liver enzymes
Anemia (low number of red blood cells)
Flu-like symptoms
Blood in urine
Skin rash
Protein in urine
an infection.
hemolytic uremic syndrome, a condition that affects the kidney and the blood.
decreased function of bone marrow.
anemia.
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
Celgem 1000mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Celgem 1000mg Injection may cause excessive drowsiness with alcohol.
Celgem 1000mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Gemcitabine is indicated for the treatment of locally advanced or metastatic bladder cancer in combination with cisplatin. Gemcitabine is indicated for treatment of patients with locally advanced or metastatic adenocarcinoma of the pancreas.
cardiovascular dysfunction.
hemolytic uremic syndrome.
myelosuppression.
cerebrovascular disease.
edema.
hepatic dysfunction.
paresthesia.
Kindly do not self administer.
BELOW 30 degrees C.
Consult a doctor before taking any medicines
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
