Manufacturer: Celon Laboratories Ltd
Salt Composition : Asparaginase(5000IU)
Celginase 5000IU Injection is given as an injection by the doctor, but try to have it the same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.
Asparaginase is widely used in chemotherapeutic regimens for the treatment of acute lymphoblastic leukemia (ALL) and has led to a substantial improvement in cure rates, especially in children. Optimal therapeutic effects depend on a complete and sustained depletion of serum asparagine.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Celginase
Breathlessness
Rash
Vomiting
Angioedema (swelling of deeper layers of skin)
Edema (swelling)
Nausea
Fatigue
Increased liver enzymes
Diarrhea
Decreased blood pressure
Flushing (sense of warmth in the face, ears, neck and trunk)
Low albumin level in blood
Increased glucose level in blood
Hives
ELSPAR is contraindicated in patients with pancreatitis or a history of pancreatitis. Acute hemorrhagic pancreatitis, in some instances fatal, has been reported following asparaginase administration. “-' Asparaginase is also contraindicated in patients who have had previous anaphylactic reactions to it.
Celginase 5000IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Celginase 5000IU Injection. Please consult your doctor.
Celginase 5000IU Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Acute lymphoblastic leukemia.
Acute myeloid leukemia.
Non-Hodgkin lymphoma.
coagulation abnormalities/bleeding.
pancreatic dysfunction.
hepatic dysfunction.
hyperglycemia.
myelosuppression.
mental status changes.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
Consult a doctor before taking any medicines.
Celginase 5000IU Injection is given as an injection into the veins, muscles or under the skin by the healthcare provider.
It is advisable to drink plenty of fluids and stay hydrated while taking this medication.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, liver function and kidney function during treatment.
It can cause an increase in blood sugar levels. Hence, monitor your blood sugar level regularly.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. When should I call my doctor right away?
Get medical help right away if you have signs of allergic reaction such as difficulty breathing, rash, hives, itching, and blisters. Also, let your doctor know if you experience severe headache, chest pain, severe abdominal pain, and swelling in various parts of the body.
Q. Can Celginase 5000IU Injection damage my liver?
Celginase 5000IU Injection may affect the liver and cause serious or even life-threatening damage to the liver. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).
Q. I am experiencing nausea and extreme tiredness. Is this due to Celginase 5000IU Injection?
Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.
Q. How to get relief from diarrhea while on treatment with Celginase 5000IU Injection?
Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.
Q. I have noticed some changes in my skin after taking Celginase 5000IU Injection. What should I do?
Use a moisturizer to get relief from rashes, dry, and itchy skin during the treatment. Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing. However, if you develop yellow discoloration of your skin, inform your doctor immediately as this could be a sign of a liver problem.
Q. Can the use of Celginase 5000IU Injection cause hyperglycemia?
Yes, Celginase 5000IU Injection can cause hyperglycemia or increase blood sugar level. Monitor your sugar level regularly and immediately inform your doctor if you see a spike in your level.
Q. I am noticing swelling and frequent muscle cramps. Should I inform my doctor?
You might experience weakness, muscle cramps and swelling in different parts of your body. This is due to low levels of albumin, an important protein in your body. Consult your doctor who will recommend blood tests to monitor your albumin levels.
Q. Should I avoid any food and drinks while taking Celginase 5000IU Injection?
You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent you from becoming dehydrated, eating small, simple but nourishing snacks every few hours rather than large meals, and sucking on hard candy or popsicles to prevent nausea and vomiting.
Q. What should I avoid during my treatment with Celginase 5000IU Injection?
During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Do not have immunizations/vaccinations without the consent of your doctor. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.
