Manufacturer: Celon Laboratories Ltd
Salt Composition : Ifosfamide(1gm)
Celofos 1gm Injection is usually given as a slow infusion (drip) into a vein (intravenously) over several hours. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.
Ifosfamide is cycle-phase nonspecific. The exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active.
Ifosfamide is a prodrug that requires biotransformation to become cytotoxic. It is a structural isomer of cyclophosphamide from which it differs only in having the chlorethyl functions on different nitrogen atoms. This causes a considerable change in initial metabolism, although overall metabolism remains the same.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Celofos
Nausea
Vomiting
Anemia (low number of red blood cells)
Hair loss
Decreased white blood cell count
Infection
Blood in urine
CNS toxicity
There are very few known contraindications for the use of ifosfamide. The absolute contraindications are known hypersensitivity to the drug or its components and urinary tract outflow obstruction. Relative contraindications include myelosuppression and severe renal or hepatic impairment.
Celofos 1gm Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Celofos 1gm Injection.
Celofos 1gm Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Ifosfamide is a cytotoxic, antineoplastic drug used to manage and treat various cancers such as lymphoma, sarcoma, and lung cancer. This activity describes the indications, administration, and contraindications for ifosfamide as a valuable agent in treating various cancers
infections.
myelosuppression.
CNS toxicity.
hepatic dysfunction.
renal dysfunction.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Celofos 1gm Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Celofos 1gm Injection is used in combination with other chemotherapy medicines, radiotherapy and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes.
It is usually given as a slow infusion (drip) into a vein (intravenously) over several hours.
Drink plenty of fluids while taking this medication to minimise damage to your bladder and kidneys.
It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
Use effective measures to avoid pregnancy during treatment with this medicine and for at least 6 months after your last dose as it can be harmful to an unborn baby.
Your doctor may have your blood tested regularly to monitor your kidney, liver function and levels of blood cells in your blood.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
