Manufacturer: Zydus Cadila
Salt Composition : Cefoperazone(500mg), Sulbactam(500mg)
Vial of 1 Injection
(Inclusive of all taxes)
Celsuf 500 mg/500 mg Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms, Sulbactam is an irreversible inhibitor of β-lactamase; by binding and inhibiting β-lactamase produced by bacterial cells, sulbactam is thereby able to prevent it from reducing antibiotic activity.
Cefoperazone was 90% bound to serum proteins. The apparent volume of distribution was 10 to 13L. The half-life of the drug varied from 1.6 to 2.4 hours; serum clearance was between 75 and 96 ml/min. Urinary excretion was rapid, but only 15 to 36% of the cefoperazone dose was recovered in the urine. Sulbactam, a new beta-lactamase inhibitor, has pharmacokinetic characteristics in humans similar to those of ampicillin and amoxicillin. Its half-life in humans is approximately 1 h
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Celsuf
Diarrhea
Abnormal liver function tests
Allergic reaction
Anemia (low number of red blood cells)
diarrhea from an infection with Clostridium difficile bacteria.
low vitamin K levels.
a decrease in the blood clotting protein prothrombin.
increased risk of bleeding due to clotting disorder.
alcohol intoxication.
inflammation of the large intestine.
liver problems.
decreased kidney function.
inflammation of the liver with stoppage of bile flow.
Celsuf 500 mg/500 mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Consuming alcohol while taking Celsuf 500 mg/500 mg Injection may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Celsuf 500 mg/500 mg Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Respiratory tract infections (upper and lower)
Urinary tract infections (upper and lower)
Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections.
Septicaemia.
Meningitis.
Skin and soft tissue infections.
Bone and joint infections.
colitis.
hypoprothrombinemia.
renal/liver disease.
sodium.
dialysis.
disulfiram-like reaction.
liver disease.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Celsuf 500 mg/500 mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect. Taking probiotics along with Celsuf 500 mg/500 mg Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Stop taking Celsuf 500 mg/500 mg Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What is Celsuf 500 mg/500 mg Injection?
Celsuf 500 mg/500 mg Injection is a combination of two medicines: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic which works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefoperazone against bacteria.
Q. How long does Celsuf 500 mg/500 mg Injection takes to work?
Usually, Celsuf 500 mg/500 mg Injection starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.
Q. What if I don't get better after using Celsuf 500 mg/500 mg Injection?
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.
