Manufacturer: A N Pharmacia
Salt Composition : Chlorpromazine(50mg), Trihexyphenidyl(2mg), Trifluoperazine(5mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Chlorfluhex 50 mg/2 mg/5 mg Tablet should be taken with food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.
Chlorpromazine is a member of the typical antipsychotic or neuroleptic drug class, also known as first-generation antipsychotics (FGAs). It produces its antipsychotic effect by the post-synaptic blockade at the D2 receptors in the mesolimbic pathway
Trihexyphenidyl belongs to a class of medication called anticholinergics that work by blocking a certain natural substance (acetylcholine). This helps decrease muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson's disease
Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium
The pharmacokinetics of chlorpromazine is also not fully understood and varies per the individual and route of administration. However, the kidneys excrete approximately 43-65% of the daily dose within 24 hours. There are 5 clinically important metabolites, 4 of which are biologically active.
Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract. The onset of action is within 1 hour after oral dosing. The peak activity is noted after 2 to 3 hours. The duration of action of one single dose is 6 to 12 hours in a dose dependent manner
The pharmacokinetics for trifluoperazine are typical of phenothiazines such as chlorpromazine. It is readily absorbed from the gastrointestinal tract with peak plasma levels being reached from 1.5 to 6.0 hours after ingestion. A high interindividual variation in bioavailability has been consistently reported
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Chlorfluhex
Nausea
Constipation
Sedation
Dryness in mouth
Weight gain
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Urinary retention
Increased prolactin level in blood
Dizziness
Blurred vision
Nervousness
breast cancer.
a high prolactin level.
overweight.
anemia.
decreased blood platelets.
low levels of white blood cells.
low levels of a type of white blood cell called neutrophils.
alcoholism.
intestine infection due to the Shigella bacteria.
diarrhea from an infection with Clostridium difficile bacteria.
thyrotoxicosis.
tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue.
autonomic neuropathy.
breast cancer.
anemia.
a significant decrease in certain blood clotting cells called platelets.
low levels of a type of white blood cell called neutrophils.
a type of movement disorder called parkinsonism.
Chlorfluhex 50 mg/2 mg/5 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Chlorfluhex 50 mg/2 mg/5 mg Tablet.
Chlorfluhex 50 mg/2 mg/5 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Schizophrenia (primarily the positive symptoms)
Bipolar I acute manic type of manic-depressive illness.
Acute agitation marked by explosive hyperexcitable behavior out of proportion to the initial provocation.
To control nausea and vomiting.
Persistent singultus (chronic hiccups)
ARTANE (trihexyphenidyl) is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa
Trifluoperazine' is indicated as an adjunct in the short-term management of anxiety states, depressive symptoms secondary to anxiety, and agitation. It is also indicated in the symptomatic treatment of nausea and vomiting
dementia.
acute alcohol intoxication.
cardiovascular disease.
CNS depression.
head injury.
anticholinergic effects.
breast cancer.
dystonic reactions
arrhythmias.
autonomic neuropathy.
GI obstruction.
glaucoma.
obstructive uropathy.
tardive dyskinesia.
infectious diarrhea.
psychoses.
Some products that may interact with this drug include: anticholinergic/antispasmodic drugs (such as atropine, dicyclomine, scopolamine), drugs that increase the amount of dopamine in your body (such as cabergoline, levodopa, pergolide, ropinirole), guanethidine, lithium, phenytoin, propranolol, warfarin, other drugs
Do not chew, crush or break it. Chlorfluhex 50 mg/2 mg/5 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Chlorfluhex 50 mg/2 mg/5 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Chlorfluhex 50 mg/2 mg/5 mg Tablet is given for the treatment of schrizophenia.
It is better to take Chlorfluhex 50 mg/2 mg/5 mg Tablet at night as this medicine may produce drowsiness or sleepiness.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Inform your doctor if you are taking any antidepressants.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as Chlorfluhex 50 mg/2 mg/5 mg Tablet may affect the levels of sugar in your blood.
Avoid exposure to sunlight or tanning beds. Chlorfluhex 50 mg/2 mg/5 mg Tablet can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Keep your regular doctor's appointments so your progress can be checked.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Chlorfluhex 50 mg/2 mg/5 mg Tablet is to be taken with food.
