Manufacturer: Icon Life Sciences
Salt Composition : Sodium Valproate(200mg), Valproic Acid(87mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Chrono Tablet should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.
Sodium valproate has a broad spectrum of anticonvulsant activity, but is structurally unrelated to conventional antiepileptic drugs. Its proposed mode of action is mediated through effects on the function of brain gamma-aminobutyric acid (GABA).
Valproic acid exhibits its pharmacologic effects in a couple of ways, such as by acting on GABA (γ aminobutyric acid) levels in the CNS, blocking voltage-gated ion channels, and inhibiting histone deacetylase.
Sodium valproate (VPA) was first marketed in the United States in 1978. In this pilot study of pharmacokinetics and toxicity, VPA was added to the treatment regimens of 20 patients (10 adults and 10 children) with intractable seizures. The drug was absorbed and excreted rapidly; the mean half-life was 9.6 hours.
Summary. Valproic acid is rapidly absorbed from the gastrointestinal tract, peak concentrations being attained 1 to 2 hours after administration of the conventional tablet, but later with the enteric-coated tablets. The bioavailability of valproic acid is complete and independent of the preparation used.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Chrono
Nausea
Vomiting
Weight gain
Loss of appetite
Gum swelling
Headache
Sleepiness
Tremors
Hair loss
Liver injury
high amount of ammonium in the blood.
low amount of albumin proteins in the blood.
porphyria.
decreased blood platelets.
suicidal thoughts.
depression.
organic mental disorder.
liver problems.
Valproic acid is contraindicated in patients with hepatic disorders, significant hepatic impairment, hypersensitivity to components of the drug and class of drug, urea cycle disorders, mitochondrial disorders, or suspected disorders in patients <2-year-old, and pregnancy
Chrono Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Chrono Tablet.
Chrono Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Sodium valproate is used to treat epilepsy and bipolar disorder. It's occasionally used to prevent migraine headaches. This medicine is only available on prescription. It comes as capsules, tablets and a liquid that you swallow
Depakene (valproic acid) is indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types which include absence seizures
depression.
liver disease.
urea cycle disorders.
suicidal tendency.
HIV/CMV.
thrombocytopenia.
thyroid function tests.
urine ketone test.
Some products that may interact with this drug include: certain antidepressants (such as amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (such as ethosuximide, lamotrigine, phenytoin, rufinamide, topiramate)
Do not chew, crush or break it. Chrono Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Chrono Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Chrono Tablet for treatment and prevention of seizures.
Take it at the same time every day to maintain consistent levels in your body.
Do not drive or do anything that requires mental focus until you know how Chrono Tablet affects you.
Avoid consuming alcohol when taking Chrono Tablet, as it may cause excessive sleepiness or drowsiness.
Monitor your weight during the treatment as Chrono Tablet can cause weight gain.
Your doctor may monitor Chrono Tablet level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
Do not take Chrono Tablet if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Chrono Tablet is to be taken with food.
Q. Can the use of Chrono Tablet cause sleepiness or drowsiness?
Yes, Chrono Tablet may make you feel drowsy or sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities. Inform your doctor if you experience such an episode while taking this medicine.
Q. Can I drink alcohol while taking Chrono Tablet?
No, avoid drinking alcohol while taking Chrono Tablet. Drinking alcohol will increase the side effects caused by Chrono Tablet.
Q. Can Chrono Tablet be stopped when epilepsy symptoms are relieved?
No, Chrono Tablet should be continued as advised by the doctor. Stopping Chrono Tablet suddenly may cause the symptoms to reappear that too with increased frequency. If any problems are experienced due to Chrono Tablet, consult the doctor for re-evaluation.
Q. Will a higher than the recommended dose of Chrono Tablet be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. If the recommended doses do not relieve your symptoms or there is an increased severity of your symptoms, please consult your doctor.
Q. What are the instructions for the storage and disposal of Chrono Tablet?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
