Chymogrand Tablet (10'S)


Chymogrand Tablet should be taken with or without food. The dose and duration will depend on what you are using it for and how well it helps your symptoms. Use it regularly and do not discontinue using it until the doctor tells you it is alright to stop.



Basic Information

Mechanism Of Action

Bromelain acts on fibrinogen to give products that are similar, at least in effect, to those formed by plasmin. They are small molecular weight active peptides, which regulate prostaglandin biosynthesis and create conditions existing in the healthy organism.

In the duodenum, trypsin catalyzes the hydrolysis of peptide bonds, breaking down proteins into smaller peptides. The peptide products are then further hydrolyzed into amino acids via other proteases, rendering them available for absorption into the blood stream.

Rutoside is a natural flavone derivative. It has anti- inflammatory, anti-allergy and immunomodulating activity 20. Rutoside inhibits platelet aggregation, as well as decreasing capillary permeability, making the blood thinner and improving circulation. Rutin also strengthens the capillaries.

Pharmacokinets

Depending on the surface area and depth of the wound, bromelain blood serum concentrations of no more than 40 µg/ml are expected, with peak concentrations reached after 2 to 4 hours. The terminal half-life varied between 8.5 and 19.9 hours in studies.

Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate

Of these, rutin, also known as vitamin P or rutoside, has been explored for a number of pharmacological effects. Tea leaves, apples, and many more possess rutin as one of the active constituents. Today, rutin has been observed for its nutraceutical effect.


Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Chymogrand

No common side effects seen

Contra Indications


If you are allergic to BROMELAIN+RUTOSIDE+TRYPSIN or any other medicines, please tell your doctor. Avoid BROMELAIN+RUTOSIDE+TRYPSIN in patients who are allergic to pineapple, carrot, papaya, fennel, and pollens. BROMELAIN+RUTOSIDE+TRYPSIN is not recommended for pregnant women as it contains Bromelain, which may cause abortion or miscarriage. If you are pregnant or planning for pregnancy, please consult a doctor before taking BROMELAIN+RUTOSIDE+TRYPSIN. Before undergoing any planned surgery, inform your doctor that you are taking BROMELAIN+RUTOSIDE+TRYPSIN. It should be stopped a minimum of 2 weeks before surgery due to increased bleeding risk during and after surgery. If you have blood pressure problems, clotting or bleeding problems, infection, hematuria (blood in urine), hematemesis (vomiting blood), kidney or liver disorders, inform your doctor before taking BROMELAIN+RUTOSIDE+TRYPSIN.

Pregnancy Related Information

Information regarding the use of Chymogrand Tablet during pregnancy is not available. Please consult your doctor.


Product And Alcohol Interaction

It is not known whether it is safe to consume alcohol with Chymogrand Tablet. Please consult your doctor.


Breast Feeding Related Information

Information regarding the use of Chymogrand Tablet during breastfeeding is not available. Please consult your doctor.


Indications


Bromelain is promoted as a dietary supplement for reducing pain and swelling, especially of the nose and sinuses, gums, and other body parts after surgery or injury. It is also promoted for osteoarthritis, cancer, digestive problems, and muscle soreness. Topical bromelain is promoted for burns.
Trypsin is given to people who lack enzymes needed for digestion. It is also given in combination with bromelain and rutin for treatment of osteoarthritis. Some people apply trypsin directly to wounds and ulcers to remove dead tissue and improve healing
Rutin plays a significant role in treating edema, small blood vessel disease, varicose veins (enlarged veins), venous insufficiency, venous hypertension, superficial vein thrombosis, mouth ulcers associated with cancer treatments, and hemorrhoids

Interactions

Drug-Drug Interaction: BROMELAIN+RUTOSIDE+TRYPSIN may have interaction with pain killers (aspirin, diclofenac, ibuprofen, naproxen), blood thinners (warfarin, clopidogrel, dalteparin, enoxaparin, heparin), antibiotics (amoxicillin, demeclocycline, minocycline, tetracycline), drugs used to dissolve blood clots (alteplase, reteplase, streptokinase), high blood pressure-lowering medicines (captopril, enalapril, fosinopril, lisinopril).

Drug- Food Interaction: BROMELAIN+RUTOSIDE+TRYPSIN may interact with ginger, garlic, asafoetida, alfalfa, arnica, fenugreek, potato, soybean, licorice, red clover, celery, angelica, meadowsweet, quassia, willow, chestnut, chamomile, and clover.

Drug-Disease Interaction: If you have blood pressure problems, clotting or bleeding problems, infection, hematuria (blood in urine), hematemesis (vomiting blood), kidney or liver disorders, inform your doctor before taking BROMELAIN+RUTOSIDE+TRYPSIN.

Typical Dosage

Do not chew, crush or break it. Chymogrand Tablet may be taken with or without food, but it is better to take it at a fixed time.


Storage Requirements

STORE BELOW 30 DEGREES C. 

Effects Of Missed Dosage

If you miss a dose of Chymogrand Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.


Effects Of Overdose

Consult a doctor before taking any medicines.


Expert Advice

Chymogrand Tablet helps relieve pain and inflammation that may occur due to trauma, surgery or everyday activity.

It may also be used to relieve inflammation in rheumatic and degenerative conditions, such as rheumatoid arthritis and osteoarthritis.

Take it with plenty of fluids, an hour before or two hours after a meal.

It may increase the severity of your condition at the start of treatment. Continue using it as prescribed by your doctor.

It may cause dizziness and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you.

It may change the color, consistency, and odor of your stool. This is harmless. Inform your doctor if this bothers you.

How To Use

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Chymogrand Tablet may be taken with or without food, but it is better to take it at a fixed time.


FAQs

Q. What is Chymogrand Tablet used for?

This is a combination of three medicines: Bromelain, Trypsin and Rutoside. Bromelain and Trypsin are enzymes which increase blood supply in the affected area and help the body produce substances that fight pain and swelling. Rutoside is an antioxidant which protects the body from any damage caused by chemicals (free radicals) and further reduces swelling.

Q. Is trypsin a hormone?

No, Trypsin is not a hormone. It is an enzyme, a protein and an endopeptidase.

Q. What is the recommended storage condition for Chymogrand Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.