Manufacturer: RPG Life Sciences Ltd
Salt Composition : Imipenem(500mg), Cilastatin(500mg)
Cilaspenem 500 mg/500 mg Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the medicine should be completed even if you feel better.
Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation
Imipenem is metabolized by renal dehydropeptidase. Approximately 70% of imipenem is excreted in the urine as the parent drug. When given via IV injection imipenem has a half-life of 1 h. The apparent half-life of the IM injection ranges from 1.3-5.1 h, likely due to slower absorption form the injection site
Cilastatin is a renal dehydropeptidase-I inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to block the metabolism of imipenem. Cilastatin has a volume of distribution of 14.6-20.1L.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cilaspenem
Nausea
Vomiting
Diarrhea
Rash
diarrhea from an infection with Clostridium difficile bacteria.
a low seizure threshold.
seizures.
chronic kidney disease stage 2 (mild)
chronic kidney disease stage 3A (moderate)
chronic kidney disease stage 3B (moderate)
chronic kidney disease stage 4 (severe)
Cilaspenem 500 mg/500 mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cilaspenem 500 mg/500 mg Injection. Please consult your doctor.
Cilaspenem 500 mg/500 mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Imipenem is indicated, in combination with cilastatin with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract, and intra-abdominal as well as septicemia and endocarditis.
BCG intravesical live.
cholera vaccine.
divalproex sodium.
ganciclovir.
probenecid.
valacyclovir.
valproic acid
Kindly do not self administer.
Store below 30°C
If you miss a dose of Cilaspenem 500 mg/500 mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Cilaspenem 500 mg/500 mg Injection is used to treat severe bacterial infections, including those acquired in hospital and those involving many different types of bacteria.
It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes.
Tell you doctor if you are allergic to penicillin as this medicine should be avoided or used with caution in penicillin allergy.
Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. For how long is Cilaspenem 500 mg/500 mg Injection used?
Duration of treatment with Cilaspenem 500 mg/500 mg Injection depends on the severity of your infection, which will be decided by your doctor.
Q. How long does Cilaspenem 500 mg/500 mg Injection take to work?
Usually, Cilaspenem 500 mg/500 mg Injection starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.
