Manufacturer: Biochem Pharmaceutical Industries
Salt Composition : Domperidone(15mg), Cinnarizine(20mg)
Cinirone-D Tablet is taken without food in a dose and duration as advised by the doctor. It is better to take it with food to avoid stomach upset. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
The DA2-receptor antagonist domperidone antagonizes the inhibitory effect of dopamine, resulting in stimulation of gastric muscle contraction. This provides a mechanism for the gastrokinetic effect of domperidone
Cinnarizine inhibits smooth muscle cell contraction in the vasculature by blocking L-and T-type voltage-gated calcium channel. It is also known to bind to histamine H1 receptors, muscarinic (acetyl choline) receptors and dopamine D2 receptors
The absorption of domperidone was very rapid, with mean peak plasma concentration (Cmax) values of 18.8, 15.0, and 20.7 ng/mL attained at 0.9, 1.2, and 0.6 hours after the administration of base tablet, maleate tablet, and solution, respectively. The mean elimination half-life (t1/2) ranged from 12.6 to 16.0 hours
Cinnarizine is most commonly taken orally, in tablet form, with frequency and amount of dosage varying depending on the reason for taking the medication. Once ingested, the substance is absorbed quite rapidly and reaches a peak plasma concentration in 1–3 hours post-administration.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cinirone-D
Nausea
Dryness in mouth
Indigestion
Sleepiness
Weight gain
with conditions where cardiac conduction is, or could be, impaired.
with underlying cardiac diseases such as congestive heart failure.
receiving other medications known to prolong QT interval or potent CYP3A4 inhibitors.
with severe hepatic impairment.
If you are allergic to Cinnarizine.
If you are pregnant or breastfeeding mother.
If you have liver or kidney problem.
If you have Parkinson's disease or porphyria
Cinirone-D Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Cinirone-D Tablet may cause excessive drowsiness with alcohol.
Information regarding the use of Cinirone-D Tablet during breastfeeding is not available. Please consult your doctor.
Domepridone is indicated for the relief of the symptoms of nausea and vomiting. Domeperidone should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting. It is recommended to take oral domperidone tablets before meals
This medication is an antihistamine, prescribed for the control of nausea and vomiting due to motion sickness. It is also used for vertigo and brain disorder. It blocks the histamine action, which reduces allergy symptoms
amiodarone.
antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
antipsychotic medications (e.g., haloperidol, pimozide, risperidone, quetiapine, ziprasidone)
aprepitant.
atropine.
Acebutolol Cinnarizine may increase the arrhythmogenic activities of Acebutolol.
Aceclofenac The risk or severity of hyperkalemia can be increased when Cinnarizine is combined with Aceclofenac.
Do not chew, crush or break it. Cinirone-D Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Cinirone-D Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
You have been prescribed Cinirone-D Tablet to relieve vertigo (dizziness) and nausea associated with it. It can make you feel dizzy, rise slowly if you have been sitting or lying down for a long time.
Take it at the same time each day to maintain a steady amount of the medicine in your body.
Do not take it for longer than 7 days without consulting your doctor.
Cinirone-D Tablet can only decrease the number and severity of attacks but may not completely stop them.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cinirone-D Tablet is to be taken empty stomach.
Q. Can I stop taking Cinirone-D Tablet if I feel well?
You should continue to take Cinirone-D Tablet until your doctor asks you to stop it. If you stop taking Cinirone-D Tablet sooner than advised, the symptoms of vertigo may reappear (dizziness and spinning).
Q. What are the instructions for the storage and disposal of Cinirone-D Tablet?
Keep this medicine in the packet or container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Cinirone-D Tablet cause drowsiness?
Yes, Cinirone-D Tablet can make you feel drowsy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities until you know how this medicine affects you.
Q. What if I accidentally take too much of Cinirone-D Tablet?
Visit the nearest emergency department if you accidentally take too much of Cinirone-D Tablet.
Q. What if I miss a dose of Cinirone-D Tablet?
If you miss a dose of Cinirone-D Tablet, you should skip the missed dose and take the next dose at its usual time and quantity. You should not take a double dose of Cinirone-D Tablet to make up for a missed dose.
