Manufacturer: Cipla Ltd
Salt Composition : Chlorzoxazone(500mg), Diclofenac(50mg), Paracetamol(325mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Cip-Zox Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.
Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors
Analysis of plasma samples indicated a rapid absorption and rapid elimination of chlorzoxazone. Average values of the elimination half-life and plasma clearance were 1.12 +/- 0.48 hr and 148.0 +/- 39.9 ml/min, respectively.
Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cip-Zox
Nausea
Vomiting
Heartburn
Stomach pain
Diarrhea
Loss of appetite
Dryness in mouth
Chlorzoxazone is contraindicated in any patient with a known or suspected intolerance or hypersensitivity to the drug or any of the product ingredients. If a sensitivity reaction such as urticaria, pruritus, or skin erythema occurs, discontinue chlorzoxazone. Angioedema or anaphylactic reactions are extremely rare.meningitis not due to an infection.
systemic mastocytosis.
dehydration.
hepatic porphyria.
anemia.
increased risk of bleeding due to clotting disorder.
an increased risk of bleeding.
alcoholism.
caloric undernutrition.
acute liver failure.
liver problems.
a condition where the body is unable to maintain adequate blood flow called shock.
acetaminophen overdose.
acute inflammation of the liver due to hepatitis C virus.
Information regarding the use of Cip-Zox Tablet during pregnancy is not available. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cip-Zox Tablet. Please consult your doctor.
Information regarding the use of Cip-Zox Tablet during breastfeeding is not available. Please consult your doctor.
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
Diclofenac is indicated for treatment of primary dysmenorrhea, for relief of mild to moderate pain, for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis, for relief of symptoms of ankylosing spondylitis and for relief of acute migraine symptoms.
Acetaminophen or paracetamol helps to reduce fever and to relieve a headache with mild to moderate pain. It is also used with other pain medications to treat low back pain, osteoarthritis, cold, and toothache
Buprenorphine Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The metabolism of Chlorzoxazone can be decreased when combined with Bupropion
asthma.
fluid retention.
GI toxicity.
rash.
renal toxicities.
thrombosis.
porphyria.
anemia.
Despite its frequent coadministration with other drugs and widespread use, very few clinically significant drug interactions have been documented with paracetamol. Drugs that alter gastric emptying can alter paracetamol pharmacokinetics, but this does not result in toxicity in therapeutic use
Do not chew, crush or break it. Cip-Zox Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Cip-Zox Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
You have been prescribed Cip-Zox Tablet to relieve pain due to muscle spasm.
This medicine is most effective when taken along with proper rest and physical therapy.
Avoid consuming alcohol when taking Cip-Zox Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
Older adults may have increased drowsiness, confusion, and higher risk of falling as a result of taking Cip-Zox Tablet.
Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cip-Zox Tablet is to be taken with food.
Q. What is Cip-Zox Tablet?
Cip-Zox Tablet is a combination of three medicines: Diclofenac, Paracetamol, and Chlorzoxazone. This medication helps in relieving muscle pain. Chlorzoxazone is a muscle relaxant which works by acting on the central nervous system. Diclofenac and Paracetamol work by lowering the chemical substance (prostaglandins) in the body that causes pain and inflammation.
Q. Is it safe to use Cip-Zox Tablet?
Cip-Zox Tablet is safe for most of the patients. However, in some patients it may cause common side effects like nausea, vomiting, heartburn, stomach pain, diarrhea, loss of appetite, dryness in the mouth, weakness, sleepiness and other uncommon or rare side effects. Inform your doctor as soon as possible if you experience any persistent problem due to the medication.
Q. Can I stop taking Cip-Zox Tablet when my pain is relieved?
Cip-Zox Tablet should be continued if advised for a specific time duration by your doctor. However, it can be discontinued if you are using it for short-term pain relief.
Q. Can the use of Cip-Zox Tablet cause nausea and vomiting?
Yes, the use of Cip-Zox Tablet can cause nausea and vomiting. In case, you experience nausea while taking this medicine, take it with milk, food or with antacids. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to your doctor.
Q. Can the use of Cip-Zox Tablet cause dizziness?
Yes, the use of Cip-Zox Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for sometime and resume once you feel better.
Q. Can the use of Cip-Zox Tablet cause damage to kidneys?
Yes, the long-term use of Cip-Zox Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
Q. Can I take a higher than the recommended dose of this medicine?
No, taking a higher than the recommended dose of Cip-Zox Tablet can increase the risks of side effects. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Q. What are the recommended storage conditions for Cip-Zox Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
