Manufacturer: Gland Pharma Limited
Salt Composition : Cisplatin(50mg)
Cisglan 50mg Infusion is given as an injection into veins by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells.
The pharmacokinetics[PK] of cisplatin are complicated. It is demonstrated that the analysis of PK for free platinum is appropriate to predict the pharmacodynamic [PD] effect of the drug. Cisplatin is considered to be an AUG dependent drug, which means that the administration schedule does not influence the PD effect
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cisglan
Injection site reactions (pain, swelling, redness)
Increased risk of infection
Ear disorder
Vomiting
Nausea
Decreased blood cells (red cells, white cells, and platelets)
Renal impairment
Peripheral neuropathy (tingling and numbness of feet and hand)
Kidney damage
Hearing loss
Ringing in ear
a bad infection.
acute leukemia.
low amount of magnesium in the blood.
low amount of calcium in the blood.
low amount of sodium in the blood.
low amount of potassium in the blood.
hemolytic uremic syndrome, a condition that affects the kidney and the blood.
anemia
Cisglan 50mg Infusion is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cisglan 50mg Infusion. Please consult your doctor.
Cisglan 50mg Infusion is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Adult indications: Cisplatin is FDA approved for the treatment of advanced ovarian cancer, testicular cancer, and bladder carcinoma. However, clinicians frequently use cisplatin off-label when the benefits may outweigh the risks of adverse drug effects.
infections.
hearing loss.
myelosuppression.
peripheral neuropathy.
renal dysfunction.
hemolytic anemia.
ocular toxicity.
Kindly do not self-administer.
Store below 30°C
If you miss a dose of Cisglan 50mg Infusion, please consult your doctor.
Consult a doctor before taking any medicines.
Cisglan 50mg Infusion is given as an injection under the supervision of a doctor.
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
Q. Is Cisglan 50mg Infusion an anticancer medicine?
Yes, Cisglan 50mg Infusion is an anticancer medicine that is used for the treatment of ovarian, cervical, and testicular cancer.
Q. How will you know that Cisglan 50mg Infusion is working?
Keep taking this medicine exactly as directed until your doctor tells you to stop. Regular scans will reveal whether your tumor is responding to the treatment. Your doctor will determine when those scans should be scheduled.
Q. Are there any serious side effects of Cisglan 50mg Infusion?
You need to seek medical help immediately if you notice severe allergic reactions like rashes, difficulty breathing, swelling of face, lips, tongue, change in heartbeats, uncontrollable nausea and vomiting, reduced urination, swelling of feet or lower legs, pain in the lower back or side, muscle cramps, paralysis or numbness of the face, arm or leg and unusual bleeding such as bleeding gum, blood in urine or stools.
Q. Does Cisglan 50mg Infusion cause hair loss?
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Q. Are there any precautions for tingling sensation and numbness in my arms and legs?
This medicine causes tingling, numbness, pain, or burning sensation in your arms or legs. Be careful when moving around, as the numbness may make it harder to walk, feel your hands or feet, or increase your risk of falls. Talk to your doctor if you feel these symptoms. You may need to change your dose or schedule.
Q. I have noticed some changes in my skin after taking Cisglan 50mg Infusion? What should I do?
Use a moisturizer to get relief from rashes, dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen with (SPF more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water bath and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.
Q. I am experiencing nausea and vomiting. Is this due to Cisglan 50mg Infusion?
Nausea and vomiting are some of the common side-effects of this medicine. Your doctor might prescribe you medications to prevent you from feeling sick. Your symptoms will be better managed if you take your medication regularly to prevent sickness rather than use it only when sickness occurs. Along with that, eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty, and drink plenty of water.
Q. Can I drink alcohol while taking Cisglan 50mg Infusion?
Avoid alcohol while on treatment with this medicine. This is because side effects like dizziness and drowsiness might become worse.
Q. What precautions should I take to reduce the chances of getting infected during treatment with Cisglan 50mg Infusion?
Since Cisglan 50mg Infusion lowers the number of white blood cells and platelets in your blood, it puts you at risk of getting an infection or bleeding. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get a fever, chills, cough; be careful not to cut yourself when you are using sharp objects such as a razor or nail cutters, and use a toothbrush with soft bristles to prevent bleeding from gums.
