Manufacturer: Indian Drugs & Pharmaceuticals Ltd
Salt Composition : Domperidone(10mg), Omeprazole(20mg)
Strip of 10 Capsule
(Inclusive of all taxes)
Cisome 10 mg/20 mg Capsule is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.
It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production.
The absorption of domperidone was very rapid, with mean peak plasma concentration (Cmax) values of 18.8, 15.0, and 20.7 ng/mL attained at 0.9, 1.2, and 0.6 hours after the administration of base tablet, maleate tablet, and solution, respectively. The mean elimination half-life (t1/2) ranged from 12.6 to 16.0 hours
The absorption of omeprazole takes place in the small intestine and is usually completed within 3 to 6 hours. The systemic bioavailability of omeprazole after repeated doses is about 60%. Omeprazole has a volume of distribution of 0.4 L/kg.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cisome
Diarrhea
Stomach pain
Dryness in mouth
Headache
Flatulence
with conditions where cardiac conduction is, or could be, impaired.
with underlying cardiac diseases such as congestive heart failure.
receiving other medications known to prolong QT interval or potent CYP3A4 inhibitors.
with severe hepatic impairment
diarrhea from an infection with Clostridium difficile bacteria.
inadequate vitamin B12.
low amount of magnesium in the blood.
liver problems.
a type of kidney inflammation called interstitial nephritis.
subacute cutaneous lupus erythematosus.
systemic lupus erythematosus, an autoimmune disease.
Cisome 10 mg/20 mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Caution is advised when consuming alcohol with Cisome 10 mg/20 mg Capsule. Please consult your doctor.
Cisome 10 mg/20 mg Capsule is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Domepridone is indicated for the relief of the symptoms of nausea and vomiting. Domeperidone should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting. It is recommended to take oral domperidone tablets before meals.
Omeprazole is indicated for the short-term treatment of peptic ulcer disease in adults, where most patients heal within four weeks.
Patients with duodenal ulcer disease and H. ...
Omeprazole is also indicated for gastric ulcers in adults
Bepridil.
Cisapride.
Darunavir.
Dronedarone.
Fluconazole.
Ketoconazole.
Levoketoconazole.
Mesoridazine.
cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John's wort. Some products need stomach acid so that the body can absorb them properly. Omeprazole decreases stomach acid, so it may change how well these products work.
Cisome 10 mg/20 mg Capsule is to be taken empty stomach.
Store below 30°C
If you miss a dose of Cisome 10 mg/20 mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Cisome 10 mg/20 mg Capsule for the treatment of acidity and heartburn.
Take it one hour before the meal, preferably in the morning.
It is a well-tolerated medicine and provides relief for a long time.
Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
Long-term use can cause weak bones and deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
Take this medicine in the dose and duration as advised by your doctor. Cisome 10 mg/20 mg Capsule is to be taken empty stomach.
Q. Is it safe to use Cisome 10 mg/20 mg Capsule?
Yes, Cisome 10 mg/20 mg Capsule is safe for most of the patients. However, in some patients it may cause common side effects like diarrhea, stomach pain, flatulence, dryness in the mouth, dizziness, headache and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medicine.
Q. What are the contraindications of Cisome 10 mg/20 mg Capsule?
The use of Cisome 10 mg/20 mg Capsule is considered to be harmful in patients with a known hypersensitivity to omeprazole or domperidone or any other inactive ingredients present in the medicine. Cautious use is advised in patients with underlying kidney or liver disease.
Q. What is the best time to take Cisome 10 mg/20 mg Capsule?
It is best to take the medicine daily before breakfast or on an empty stomach.
Q. Can the use of Cisome 10 mg/20 mg Capsule cause abnormal heartbeat?
Yes, the use of Cisome 10 mg/20 mg Capsule can cause an increased risk of irregular heartbeat (serious arrhythmias). These are serious side effects but the chances that it may happen is very low. The risk may be slightly higher in those who are more than 60 years of age.
Q. Does the use of Cisome 10 mg/20 mg Capsule lead to dry mouth?
Yes, the use of Cisome 10 mg/20 mg Capsule can cause dry mouth. Dryness of mouth occurs due to Domperidone, which is present in this combination. If you experience dry mouth, drink plenty of water. Take regular sips of water during the day and keep some water on your bedside at night. Cut down the intake of alcohol and avoid smoking. If you have dry mouth, try to use alcohol-free mouthwash as its use increases the risk of tooth decay.
Q. What is the recommended storage condition for Cisome 10 mg/20 mg Capsule?
Keep this medicine in the container or pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
