Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Gemcitabine(1gm)
Citafine 1gm Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most important mechanism of action of gemcitabine is inhibition of DNA synthesis (Huang et al., 1991). When dFdCTP is incorporated into DNA, a single deoxynucleotide is incorporated afterwards, preventing chain elongation
Gemcitabine plasma concentrations generally reach a plateau after 15–30 min during the standard 30 min infusion protocol. Linear pharmacokinetics have been described over the range 40–3650 mg/m2, and nonlinear pharmacokinetics at higher doses
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Citafine
Nausea
Vomiting
Loss of appetite
Hair loss
Low blood platelets
Allergic reaction
Breathlessness
Decreased white blood cell count
Increased liver enzymes
Anemia (low number of red blood cells)
Flu-like symptoms
Blood in urine
Skin rash
Protein in urine
an infection.
hemolytic uremic syndrome, a condition that affects the kidney and the blood.
decreased function of bone marrow.
anemia.
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
Citafine 1gm Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Citafine 1gm Injection may cause excessive drowsiness with alcohol.
Citafine 1gm Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Gemcitabine is indicated as first-line treatment for patients with locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. Gemcitabine is indicated for patients previously treated with fluorouracil
infections.
cardiovascular dysfunction.
hemolytic uremic syndrome.
myelosuppression.
cerebrovascular disease.
edema.
hepatic dysfunction.
paresthesia.
Kindly do not self administer.
Store below 30°C
Consult a doctor before taking any medicines
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
