Manufacturer: Elder Pharmaceuticals Ltd
Salt Composition : Ciprofloxacin(500mg), Tinidazole(600mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Citoz TZ 500 mg/600 mg Tablet is a prescription medicine that is advised to be taken as suggested by the doctor. It should be taken with food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as an overdose of it may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better to ensure a complete recovery.
It inhibits DNA replication by inhibiting bacterial DNA topoisomerase and DNA-gyrase. Of the fluoroquinolone class, ciprofloxacin is the most potent against gram-negative bacilli bacteria
Tinidazole is an antiprotozoal, antibacterial agent. The nitro- group of tinidazole is reduced by cell extracts of Trichomonas. The free nitro- radical generated as a result of this reduction may be responsible for the antiprotozoal activity.
The pharmacokinetics of ciprofloxacin in healthy volunteers include a time to peak concentrations after oral dosage (tmax) of 1–1.5 h, oral availability of 0.5–0.7, protein binding of 0.2–0.3, volume of distribution (V) of 2–3 l kg−1, half-life (t1/2) of 3–4 h and fraction excreted unchanged in the urine of 0.4–0.6
Tinidazole is excreted by the liver and the kidneys. Tinidazole is excreted in the urine mainly as unchanged drug (approximately 20-25% of the administered dose). Approximately 12% of the drug is excreted in the feces. The elimination half-life is 13.2±1.4 hours and the plasma half-life is 12 to 14 hours.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Citoz TZ
Nausea
Vomiting
Stomach pain
Dryness in mouth
Metallic taste
Headache
diarrhea from an infection with Clostridium difficile bacteria.
diabetes.
low blood sugar.
glucose-6-phosphate dehydrogenase (G6PD) deficiency.
low amount of magnesium in the blood.
low amount of potassium in the blood.
a low seizure threshold.
Contraindicated in patients with a prior history of hypersensitivity to tinidazole or other nitroimidazole derivatives and during the first trimester of pregnancy. Use with caution and reduce dose in severe hepatic Impairment.
Citoz TZ 500 mg/600 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Citoz TZ 500 mg/600 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Citoz TZ 500 mg/600 mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Baby should be closely monitored for development of fever, loss of appetite and diarrhea. In case, any of the above happens please inform your doctor immediately.
Infections of the gastro-intestinal tract and intra-abdominal infections Typhoid fever
Intra-abdominal infections due to Gram-negative bacteria
Infections of the skin and soft tissue
Bone and joint infections
Tinidazole is indicated for the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in non-pregnant women
colitis.
CNS disorders.
myasthenia gravis.
peripheral neuropathy.
QT interval prolongation.
tendonitis.
crystalluria.
diabetes.
blood dyscrasias.
neurologic toxicity.
alcoholism.
hemodialysis.
liver disease.
Do not chew, crush or break it. Citoz TZ 500 mg/600 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Citoz TZ 500 mg/600 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Your doctor has prescribed this combination medicine for the treatment of diarrhea and dysentery.
Diarrhea can cause dehydration. Drink plenty of fluids to help rehydrate you.
Consult your doctor if your diarrhea lasts for more than 48 hours.
Do not use Citoz TZ 500 mg/600 mg Tablet if you have blood in your stool or if you are severely constipated.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
Avoid consuming alcohol when taking Citoz TZ 500 mg/600 mg Tablet as it may irritate your stomach and also cause excessive drowsiness.
Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Citoz TZ 500 mg/600 mg Tablet is to be taken with food.
Q. What is Citoz TZ 500 mg/600 mg Tablet?
Citoz TZ 500 mg/600 mg Tablet is a combination of two medicines: Tinidazole and Ciprofloxacin. They work by killing the harmful microorganisms that can cause infection. Together they help to treat the infection more effectively.
Q. Is it safe to use Citoz TZ 500 mg/600 mg Tablet?
Citoz TZ 500 mg/600 mg Tablet is safe for most of the patients. However, in some patients it may cause common side effects like nausea, vomiting, stomach pain, dizziness, headache, dryness in the mouth, metallic taste, heartburn and other uncommon or rare side effects. If you experience any problem due to the medication, inform your doctor as soon as possible.
Q. What if I don't get better after using Citoz TZ 500 mg/600 mg Tablet?
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.
Q. Can I stop taking Citoz TZ 500 mg/600 mg Tablet when I feel better?
No, do not stop taking Citoz TZ 500 mg/600 mg Tablet and complete the full course of treatment even if you are feeling better. Your symptoms may improve before the infection is completely cured.
Q. What if I miss my dose?
Take Citoz TZ 500 mg/600 mg Tablet as soon as you remember it. However, do not take it if it's almost time for your next dose. Also, do not take an extra dose to make up for your missed dose.
