Manufacturer: Hetero Drugs Ltd
Salt Composition : Bevacizumab(100mg/4ml)
Cizumab 100 Solution for Infusion is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Cizumab 100 Solution for Infusion as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.
Bevacizumab acts by selectively binding circulating VEGF, thereby inhibiting the binding of VEGF to its cell surface receptors. This inhibition leads to a reduction in microvascular growth of tumor blood vessels and thus limits the blood supply to tumor tissues.
A population pharmacokinetic (PK) model has been previously developed. Bevacizumab PK showed dose linearity within the dose range of 1–20 mg/kg, a slow clearance, a volume of distribution consistent with limited extravascular distribution and a terminal half-life of approximately 20 days
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Cizumab
Rectal bleeding
Taste change
Headache
Nosebleeds
Back pain
Dry skin
High blood pressure
Protein in urine
Inflammation of the nose
Patients were classified as having a contraindication if they had at least two claims within 12 months before first bevacizumab for any of the following diagnoses: severe cardiac disease, thrombosis, hemorrhage, stroke, hemoptysis, or colon perforation.
Cizumab 100 Solution for Infusion may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Cizumab 100 Solution for Infusion. Please consult your doctor.
Cizumab 100 Solution for Infusion is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Stage III or IV ovarian cancer (OC) after primary surgery. ...
Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (rOC) ...
Persistent, recurrent, or metastatic cervical cancer (CC) ...
Metastatic renal cell carcinoma (mRCC) ...
Recurrent glioblastoma (GBM)
fistula formation.
GI perforation.
bleeding.
hypertension.
PRES.
proteinuria.
thromboembolic disorders.
Kindly do not self-administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Cizumab 100 Solution for Infusion, please consult your doctor.
Consult a doctor before taking any medicines.
Cizumab 100 Solution for Infusion is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
Cizumab 100 Solution for Infusion is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Cizumab 100 Solution for Infusion.
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
Q. What kinds of cancer can Cizumab 100 Solution for Infusion be used for ?
Cizumab 100 Solution for Infusion is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).
Q. How is Cizumab 100 Solution for Infusion given?
Cizumab 100 Solution for Infusion is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.
Q. How long can I take Cizumab 100 Solution for Infusion for?
You keep taking Cizumab 100 Solution for Infusion as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Cizumab 100 Solution for Infusion. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.
Q. How Cizumab 100 Solution for Infusion works differently from chemotherapy?
Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Cizumab 100 Solution for Infusion is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.
Q. Does a person taking Cizumab 100 Solution for Infusion still need chemotherapy?
Chemotherapy is still needed along with taking Cizumab 100 Solution for Infusion. It makes chemotherapy work better.
