Manufacturer: Glaxo SmithKline Pharmaceuticals Ltd
Salt Composition : Benzoyl Peroxide(5% w/w), Clindamycin(1% w/w)
Clindoxyl Gel should be used in the dose and duration as advised by your doctor. It is for external use only. Wash your hands before using this medicine. Apply only on the affected areas of the skin. It is advised to check the label for directions before use. The most common side effects include skin peeling, redness, dry skin and burning and sensation at the application site.
Topical benzoyl peroxide exhibits bactericidal effects against Cutibacterium acnes, a key component of acne vulgaris. Benzoyl peroxide, once absorbed by the skin, is converted to benzoic acid. Approximately 5% of the benzoic acid is systemically absorbed and excreted by the renal system.
Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Clindamycin is bacteriostatic
In the skin, benzoyl peroxide is metabolized to benzoic acid. Approximately 5% of the benzoic acid is systemically absorbed and excreted in the urine. After topical application to the skin, benzoyl peroxide is absorbed through the epidermis. Approximately 5% of the benzoic acid is systemically absorbed.
Clindamycin is absorbed well orally and can be given parenterally. Clindamycin diffuses well into body fluids except cerebrospinal fluid; it is concentrated in phagocytes. Most of the drug is metabolized; metabolites are excreted in bile and urine
Erythema (skin redness)
Skin peeling
Dryness
Burning sensation
Itching
Stinging sensation
General Information. Benzoyl peroxide is contraindicated in individuals having known sensitivity to benzoyl peroxide or any other listed ingredients.
Skin abrasion, skin disease, sunburn, sunlight (UV) exposure. ...
Accidental exposure, ocular exposure. ...
Children. ...
Pregnancy. ...
Breast-feeding.
diarrhea from an infection with Clostridium difficile bacteria.
myasthenia gravis, a skeletal muscle disorder.
Crohn's disease.
ulcerative colitis, an inflammatory condition of the intestines.
severe liver disease.
blood in the bowel movement.
severe renal impairment.
Clindoxyl Gel may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Clindoxyl Gel is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Benzoyl peroxide is also indicated in combination with tretinoin for the treatment of acne vulgaris in patients aged nine years and older. Topical benzoyl peroxide is also indicated for the treatment of inflammatory lesions of rosacea in adults
Clindamycin is indicated for the treatment of pelvic infections including pelvic inflammatory disease, pelvic abscesses, endometritis and bacterial vaginosis
Cisatracurium The risk or severity of neuromuscular blockade can be increased when Clindamycin is combined with Cisatracurium.
Clarithromycin The metabolism of Clindamycin can be decreased when combined with Clarithromycin
Concomitant use of other photosensitizing agents like benzoyl peroxide may increase the risk of a photosensitivity reaction. Salicylic Acid: (Moderate) Concurrent use of benzoyl peroxide and topical products containing salicylic acid on the same area of skin will cause additive irritant and drying effects
Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Clindoxyl Gel, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Clindoxyl Gel for the treatment of acne.
It is recommended that you use a mild soap and lukewarm water to wash with, as very hot or cold water may worsen acne. Do not wash more than you normally do.
Apply a thin layer on the affected area. It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
Avoid contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the cream in these areas.
During your treatment, your doctor may ask you to use another (non-antibiotic) skin preparation from time to time. It is important that you follow your doctor's advice, as this is to help prevent your acne from becoming resistant to treatment.
You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day. If, however, your skin has not improved even after completing the prescribed time, consult your doctor.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
Q. Can I use Clindoxyl Gel as a spot treatment (single pimple)?
It is not a spot treatment and should not be used to treat a single pimple. Clindoxyl Gel should be applied to the entire face. Using it once every day can treat your acne.
Q. How long does Clindoxyl Gel take to work?
It may take up to 2-3 weeks before your symptoms improve. Clindoxyl Gel may take some time to deliver significant results. Use the medicine as directed and tell your doctor if your symptoms do not improve or if they get worse.
Q. Will Clindoxyl Gel be more effective if I overuse it?
No, do not overuse Clindoxyl Gel. It can result in too much medicine being absorbed into the body and cause severe diarrhea. If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation.
Q. What are the instructions for the storage and disposal of Clindoxyl Gel?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
