Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Paclitaxel(300mg)
It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Mechanism of action of paclitaxel. Paclitaxel targets microtubules. At high concentration, PTX causes mitotic arrest at G2/M phase whereas at low concentration, apoptosis is induced at G0 and G1/S phase either via Raf-1 kinase activation or p53/p21 depending on the dose concentration.
Paclitaxel is a new anticancer agent showing significant promise as therapy for solid tumours and leukaemia, given alone or in combination with other chemotherapeutic agents. Paclitaxel concentrations in biological specimens can be measured using high performance liquid chromatography, or more recently by immunoassay.
Nausea
Vomiting
Weakness
Low blood platelets
Rash
Upper respiratory tract infection
Urinary tract infection
Bleeding
Anemia (low number of red blood cells)
Flushing (sense of warmth in the face, ears, neck and trunk)
Hair loss
Decreased blood pressure
Peripheral neuropathy (tingling and numbness of feet and hand)
Diarrhea
Decreased white blood cell count (neutrophils)
Paclitaxel is contraindicated in patients with solid tumor who have baseline neutrophil counts less than 1500 cells/m³ and in patients with AIDS-related Kaposi sarcoma who have baseline neutrophil counts less than 1000 cells/m³; perform frequent peripheral blood counts to monitor for the occurrence of bone marrow
Clixel 300mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Clixel 300mg Injection.
Clixel 300mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Paclitaxel Injection, in combination with cisplatin, is indicated for the first-line treatment of non-small cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy. Paclitaxel Injection is indicated for the second-line treatment of AIDS-related Kaposi's sarcoma.
infections.
conduction disorders.
hepatic dysfunction.
myelosuppression.
peripheral neuropathy.
anaphylaxis.
Kindly do not self administer.
Store below 30°C
Consult a doctor before taking any medicines
Clixel 300mg Injection is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer, and non-small cell lung cancer.
It is given as an intravenous (IV) injection into your vein, usually over 1 hour and every three weeks.
Do not take Clixel 300mg Injection if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine.
Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection.
Talk to your doctor if you have sudden weight gain or if you have swelling in your arms and legs that doesn't go away.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Clixel 300mg Injection generic/ taxane/ FDA approved/cytotoxic?
Yes, Clixel 300mg Injection is generic/ taxane/ FDA approved/ cytotoxic
Q. Is Clixel 300mg Injection a vesicant?
Clixel 300mg Injection is usually a vesicant (irritant)
Q. Is Clixel 300mg Injection light sensitive/ hydrophobic/ cardiotoxic?
Yes, Clixel 300mg Injection is light sensitive/ hydrophobic/ cardiotoxic
Q. Does Clixel 300mg Injection cause hair loss?
Yes, Clixel 300mg Injection may cause hair loss as a side effect. Please inform your doctor about any side effect while you are on Clixel 300mg Injection therapy
Q. What is Clixel 300mg Injection derived from?
Clixel 300mg Injection is derived from bark of the Pacific yew, Taxus brevifolia.
