Manufacturer: Natco Pharma Ltd
Salt Composition : Chlorambucil(5mg)
Clokeran 5mg Tablet should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Chlorambucil, an aromatic nitrogen mustard derivative, is an alkylating agent. Chlorambucil interferes with DNA replication and induces cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of Bax, an apoptosis promoter.
Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard. The pharmacokinetic data suggests that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion
Anemia (low number of red blood cells)
Decreased blood cells (red cells, white cells, and platelets)
Decreased white blood cell count (neutrophils)
Decreased white blood cell count
Bone marrow suppression
Nausea
Vomiting
Diarrhea
Mouth ulcer
New primary malignancy. Chlorambucil may be mutagenic in humans. ...
Hepatic disease. ...
Anemia, bone marrow suppression, leukopenia, neutropenia, radiation therapy, thrombocytopenia. ...
Serious rash. ...
Head trauma, seizure disorder. ...
Vaccination. ...
Pregnancy. ...
Infertility.
Clokeran 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Clokeran 5mg Tablet. Please consult your doctor.
Clokeran 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
LEUKERAN (chlorambucil) is indicated in the treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease. It is not curative in any of these disorders but may produce clinically useful palliation.
There are no known drug/drug interactions with chlorambucil. Because of its carcinogenic properties, chlorambucil should not be given to patients with conditions other than chronic lymphatic leukemia or malignant lymphomas
Do not chew, crush or break it. Clokeran 5mg Tablet is to be taken empty stomach.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Clokeran 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Clokeran 5mg Tablet should be taken one hour before a meal or two hours after a meal.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clokeran 5mg Tablet is to be taken empty stomach.
Q. How is Clokeran 5mg Tablet administered?
Clokeran 5mg Tablet is administered orally in tablet form.
Q. Why is Clokeran 5mg Tablet toxic to cancer cells/ how does Clokeran 5mg Tablet work?
Clokeran 5mg Tablet belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.
Q. Does Clokeran 5mg Tablet cause hair loss/constipation?
No, hair loss or constipation has not been reported with the use of Clokeran 5mg Tablet.
Q. What is Clokeran 5mg Tablet used for?
Clokeran 5mg Tablet is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).
Q. How is Clokeran 5mg Tablet excreted?
Clokeran 5mg Tablet is metabolized in liver to form nontoxic compounds which are excreted in urine.
Q. Does Clokeran 5mg Tablet need to be refrigerated?
Clokeran 5mg Tablet has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.
