Manufacturer: S P Pharma
Salt Composition : Clozapine(25mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Closin 25mg Tablet may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.
The mechanism by which clozapine exerts its effects involves the blocking of 5-HT2A/5-HT2C serotonin receptors and the D1-4 dopamine receptors, with the highest affinity for the D4 dopamine receptor.
Clozapine is metabolised via the hepatic microsomal enzyme system into 2 principle metabolites: demethyl-clozapine and clozapine N-oxide. Urine samples have reported the ratio of clozapine:demethyl:N-oxide to be 1:1:2.
Increased sweating
Visual impairment
Decreased blood pressure
Neutropenia (due to the risk of agranulocytosis)
Orthostatic hypotension.
Seizures.
Myocarditis.
Dementia (risk of a cardiovascular event)
Closin 25mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Closin 25mg Tablet.
Closin 25mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If Closin 25mg Tablet is used, monitor the baby for excessive sedation. Periodically, keep a check on the baby's white blood cell count as well.
Primary indications for clozapine in patients with schizophrenia or schizoaffective disorder are schizophrenia symptoms partially or fully resistant to treatment with other antipsychotic drugs, or accompanied by persistent suicidal or self-injurious behavior
dementia.
agranulocytosis.
anticholinergic effects.
hepatitis.
acute alcohol intoxication.
CNS depression.
NMS.
tardive dyskinesia
Do not chew, crush or break it. Closin 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Closin 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Closin 25mg Tablet helps treat schizophrenia in people for whom other medicines are ineffective or not tolerated.
Take it with or without food, preferably at the same time everyday.
It can cause dizziness and sleepiness. Be cautious while driving or doing anything that requires concentration.
It may cause low blood pressure and dehydration. Drink plenty of fluids and rise slowly from a sitting or lying position.
It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Do not stop taking Closin 25mg Tablet without talking to your doctor first as it may cause worsening of symptoms.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Closin 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. How long does it take for Closin 25mg Tablet to work?
Like many medicines, Closin 25mg Tablet does not work straight away. You might start feeling more calm and relaxed after a few weeks of taking this medicine.
Q. Why has Closin 25mg Tablet been prescribed?
Closin 25mg Tablet is an antipsychotic drug used to treat manic episodes and Schizophrenia, a mood disorder. It shortens the time to recovery and prevents mania from returning. It is also used to reduce the risk of suicidal behavior in people with Schizophrenia.
Q. Does Closin 25mg Tablet help with anxiety?
Yes, Closin 25mg Tablet helps calm the mind and decreases the level of anxiety and aggressive behavior in patients with Schizophrenia.
Q. Is Closin 25mg Tablet addictive?
No, Closin 25mg Tablet is not addictive in nature. No habit-forming potential has been seen with its use. However, always follow your doctor's advice regarding the duration of its use.
Q. When should I see my doctor?
Seek immediate medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction, pain or burning when you urinate, or vaginal itching or discharge.
Q. Can Closin 25mg Tablet cause dizziness?
Yes. Closin 25mg Tablet can cause dizziness by reducing blood pressure. If this happens to you, you should sit or lie down until the symptoms pass. Always carry some sugary food or fruit juice with you in case you experience dizziness while traveling.
Q. Why do I have to have regular blood tests while I am taking Closin 25mg Tablet?
Closin 25mg Tablet is known to cause a rare but serious side effect called “agranulocytosis”. This side effect occurs in less than 1 out of every 100 people who take this medicine. This side effect can result in a decrease in the number of white blood cells (infection-fighting cells) in your body. Without enough white blood cells, your body may not be able to. In order to prevent this, your doctor may prescribe you a blood test to check your white blood cell count.
Q. Can I drink alcohol while taking Closin 25mg Tablet?
It is recommended that people taking this medicine should not drink alcohol. This is because Closin 25mg Tablet is an antipsychotic and taking it with alcohol can cause severe drowsiness. This can lead to falls and accidents. Also, drinking alcohol may make mania, depression, and anxiety worse. Discuss any concerns you have with your doctor, pharmacist, or nurse.
Q. I am experiencing a change in my taste after the start of the treatment with Closin 25mg Tablet. Any tips to reduce it?
A change in taste is a common side-effect of this medicine. Rinse your mouth with a solution of salt and bicarbonate of soda before mealtimes to neutralize the bad taste in your mouth. You may also add some extra flavor or seasonings to your food.
Q. I am having trouble remembering to take my medications. Is there anything I can do to help me remember?
In order to avoid missing a dose, use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member a friend to remind you or check in with you to be sure you are taking your medication.
Q. What happens if I stop taking Closin 25mg Tablet?
It is advisable not to stop taking this medicine without talking to your doctor, since it may worsen your symptoms. Your doctor will probably want to decrease your dose gradually.
