Manufacturer: Mankind Pharma Ltd
Salt Composition : Clotrimazole(1% w/w), Clobetasol(0.05% w/w), Neomycin(0.5% w/w)
Clostar-Gm Cream is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. Wash your hands before and after applying the medicine. If it gets into your eyes, nose, mouth, or vagina rinse with water. It may take several days to weeks for your symptoms to improve, but you should keep using this medicine regularly. The course of the treatment should be completed to ensure the better efficacy of the medicine. If your condition does not improve or gets worse, you should talk to your doctor.
Clotrimazole exerts its action primarily by damaging the permeability barrier in the fungal cytoplasmic membrane.Clotrimazole thereby inhibits the biosynthesis of ergosterol in a concentration-dependent manner by inhibiting the demethylation of 14 alpha lanosterol.
Neomycin is bactericidal in action. Similar to other aminoglycosides, it inhibits bacterial protein synthesis through irreversible binding to the 30 S ribosomal subunit of susceptible bacteria.
Clobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids. Clobetasol is a Corticosteroid. The mechanism of action of clobetasol is as a Corticosteroid Hormone Receptor Agonist.
After vaginal treatment with clotrimazole, the small fraction absorbed into the systemic circulation--between 3% and 10% of the dose--is subjected to metabolism and excretion as after oral or intravenous administration. The vaginal availability of clotrimazole is largely dependent on the formulation applied
Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators
There is limited information on the metabolism of neomycin, as there is limited systemic absorption following drug administration. Metabolism is deemed to be negligible. The small absorbed fraction of neomycin is excreted by the kidney. The unabsorbed portion of the drug is excreted unchanged in the feces.
Application site reactions (burning, irritation, itching and redness)
Avoid its use in case of any fungal infections (ringworm or athlete's foot), viral infections (herpes or chickenpox) or for treatment of acne or rosacea.
Clostar-Gm Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
No interaction found/established
Clostar-Gm Cream is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Clobetasol/neomycin/nystatin Cream is indicated in more resistant dermatoses such as recalcitrant eczemas and psoriasis (excluding widespread plaque psoriasis) where secondary bacterial or candidal infection is present, suspected or likely to occur, as when using occlusive dressings.
Clobetasol/neomycin/nystatin Cream is indicated in more resistant dermatoses such as recalcitrant eczemas and psoriasis (excluding widespread plaque psoriasis) where secondary bacterial or candidal infection is present, suspected or likely to occur, as when using occlusive dressings.
Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Store below 30°C
If you miss a dose of Clostar-Gm Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Clostar-Gm Cream must be applied as a thin layer on the affected area as prescribed by your doctor.
Do not use this medicine more often or for longer than advised by your doctor.
Before each application, wash the affected area with soap and water and dry well.
Avoid getting it in the eyes, mouth or nose. Rinse with cold water if you accidentally get it in these areas.
Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
Inform your doctor if the treated skin area does not improve after 2-4 weeks of treatment.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Q. Can I stop taking Clostar-Gm Cream when my symptoms are relieved?
No, do not stop using Clostar-Gm Cream and complete the full course of treatment, even if you feel better. Your symptoms may improve before the infection is completely cured.
Q. What precautions should I take while using Clostar-Gm Cream?
Clostar-Gm Cream should not be used on the face and any contact with the eyes should be avoided. Do not apply a bandage or dressing on the area being treated, as this will increase absorption of the medicine and increase the risk of side effects. This medicine should only be used for the condition it is prescribed for. Do not use it for any other condition without consulting your doctor. Do not give it to other people even if their condition appears to be the same.
Q. How to use Clostar-Gm Cream?
Clostar-Gm Cream should be used as advised by the doctor or as per the instructions on the label of the medicine. Apply a thin layer of Clostar-Gm Cream to cover the affected areas. The dose would depend on the condition for which it is prescribed. Wash your hands after using Clostar-Gm Cream unless it is used for treating infection of the hands. Avoid contact with the eyes.
Q. What would happen if I use a higher than the recommended dose of Clostar-Gm Cream and for long periods?
The dosage and duration of using Clostar-Gm Cream should be strictly according to the doctor’s advice. This medicine contains clobetasol which when used in higher doses and for longer periods can get absorbed in the blood and cause adrenal suppression and Cushing's syndrome. It can cause weight gain, high blood pressure and rounding of the face. Its application can lead to a change in color of skin at the site of application. Veins beneath the skin become visible due to the thinning and weakening of the skin. There could be an increased hair growth. If you experience an increased severity of your symptoms, please consult your doctor for re-evaluation.
