Manufacturer: Alembic Pharmaceuticals Ltd
Salt Composition : Tranexamic Acid(500mg), Mefenamic Acid(250mg)
Strip of 10 Tablet
(Inclusive of all taxes)
You can take Clostop Srx Tablet at any time of day, with food, but it is best to take it at the same time each day. It should be taken on first day of the periods to get the most benefit. Keep taking it for as long as advised by your doctor. Take this medicine in the dose and duration advised by the doctor and if you have missed a dose, take it as soon as you remember. Remember to finish the full course of treatment even if you feel better. Inform your doctor if you do not observe any change in periods even after 3 consecutive periods.
Tranexamic acid is a synthetic derivative of the amino acid lysine and binds the 5 lysine binding sites on plasminogen. This inhibits plasmin formation and displaces plasminogen from the fibrin surface. It may also directly inhibit plasmin and partially inhibit fibrinogenolysis at higher concentrations
Mefenamic acid has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro.
Tranexamic acid 1 g was given intravenously to three healthy volunteers. Plasma concentrations decayed in three monoexponential phases. Most elimination took place during the first eight hours, giving an apparent elimination half-life of approximately two hours. Plasma clearance ranged between 110-116 ml/min.
Mefenamic acid is metabolized by cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl mefenamic acid (Metabolite I). Further oxidation to a 3-carboxymefenamic acid (Metabolite II) may occur. The activity of these metabolites has not been studied.
Nausea
Vomiting
Heartburn
Indigestion
Diarrhea
Loss of appetite
Nasal congestion (stuffy nose)
Headache
Tiredness
Musculoskeletal (bone, muscle or joint) pain
Anemia (low number of red blood cells)
Stomach pain
Sinus pain
Sinus inflammation
increased risk of blood clotting.
fluid accumulation in the brain.
a clot in the small veins that carry blood to or from the retina of the eye.
a heart attack.
acute blood clot in a blood vessel supplying the lungs.
heart valve disease.
Mefenamic acid is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactoid reactions to mefenamic acid have been reported in such patients
Clostop Srx Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Clostop Srx Tablet.
Clostop Srx Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Menorrhagia. Indicated for the treatment of cyclic heavy menstrual bleeding.
Hereditary Angioedema
Cone Biopsy
Epistaxis
Hyphema
Hereditary Angioedema
Administration.
Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation
Some products that may interact with this drug include: "blood thinners" (anticoagulants such as warfarin, heparin), drugs that prevent bleeding (including factor IX complex, anti-inhibitor coagulant concentrates), estrogens, hormonal birth control (such as pills, patch, ring), tibolone, tretinoin.
Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (such as prednisone), fluconazole, ketorolac, lithium, methotrexate, "water pills" (diuretics such as furosemide).
Do not chew, crush or break it. Clostop Srx Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Clostop Srx Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Clostop Srx Tablet helps relieve menstrual pain and abnormally heavy menstrual bleeding.
Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
Take it with food to avoid an upset stomach.
Take it on the first day of a heavy period. Taking it before or after will not have any benefit.
Inform your doctor if there is no improvement in your bleeding after using this medicine for three consecutive menstrual periods.
Inform your doctor if you have a history of kidney or liver disease.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clostop Srx Tablet is to be taken with food.
Q. What is Clostop Srx Tablet?
Clostop Srx Tablet is a combination of two medicines: Tranexamic Acid and Mefenamic Acid. This medication is used to treat pain and is used to treat heavy bleeding during menstrual cycle (monthly periods) in women.
Q. Are there any specific contraindications associated with the use of Clostop Srx Tablet?
Yes, it is considered to be harmful for patients with severe kidney failure, active intravascular clotting (obstruction in the blood flow due to blood clots), and color vision disorders.
Q. What is the recommended storage condition for Clostop Srx Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
