Manufacturer: La Pharmaceuticals
Salt Composition : Chlordiazepoxide(10mg), Trifluoperazine(1mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Cloxide Plus 10 mg/1 mg Tablet can be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop this medication suddenly as it may cause withdrawal symptoms.
Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Anti-anxiety action of chlordiazepoxide is believed to result from stimulation of GABA receptors in the ascending reticular activating system, since GABA in inhibitory receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brainstem reticular formation
Chlordiazepoxide is a long-acting benzodiazepine drug. The half-life of Chlordiazepoxide is 5 – 30 hours but has an active benzodiazepine metabolite (desmethyldiazepam), which has a half-life of 36 – 200 hours
The pharmacokinetics for trifluoperazine are typical of phenothiazines such as chlorpromazine. It is readily absorbed from the gastrointestinal tract with peak plasma levels being reached from 1.5 to 6.0 hours after ingestion. A high interindividual variation in bioavailability has been consistently reported
Sedation
Confusion
Weight gain
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Memory impairment
Urinary retention
Dizziness
Increased prolactin level in blood
Tiredness
Tremors
Muscle stiffness
Uncoordinated body movements
Dryness in mouth
Constipation
porphyria.
psychotic disorder.
suicidal thoughts.
alcohol intoxication.
drug abuse.
depression.
worsening of debilitating chronic lung disease called COPD.
decreased lung function.
breast cancer.
anemia.
a significant decrease in certain blood clotting cells called platelets.
low levels of a type of white blood cell called neutrophils.
a type of movement disorder called parkinsonism.
Cloxide Plus 10 mg/1 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Cloxide Plus 10 mg/1 mg Tablet.
Cloxide Plus 10 mg/1 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Chlordiazepoxide and trifluoperazine. Chlordiazepoxide works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain. Trifluoperazine is a typical antipsychotic
Antacids, certain anti-depressants (such as fluoxetine, fluvoxamine, nefazodone), cimetidine, clozapine, digoxin, disulfiram, kava, sodium oxybate.
Anticholinergic/antispasmodic drugs (such as atropine, dicyclomine, scopolamine), drugs that increase the amount of dopamine in your body (such as cabergoline, levodopa, pergolide, ropinirole), guanethidine, lithium, phenytoin, propranolol, warfarin, other drugs
Do not chew, crush or break it. Cloxide Plus 10 mg/1 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Cloxide Plus 10 mg/1 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Cloxide Plus 10 mg/1 mg Tablet is used for the treatment of schizophrenia.
It is better to take Cloxide Plus 10 mg/1 mg Tablet at night as this medicine may produce drowsiness or sleepiness.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Avoid exposure to sunlight or tanning beds. Cloxide Plus 10 mg/1 mg Tablet can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cloxide Plus 10 mg/1 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
